Improved performance of ischemic canine myocardium in response to nifedipine and diltiazem.
Improved performance of ischemic canine myocardium in response to nifedipine and diltiazem.
复制标题
改善缺血犬心肌对硝苯地平和地尔硫卓的反应性能。
DOI：
10.1152/ajpheart.1980.239.5.h658
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Henry,PD
中科院分区：
文献类型：
--
作者：
Perez,JE;Sobel,BE;Henry,PD
为了研究Ca2+拮抗剂对缺血心肌功能的影响，我们给氯氯麻醉的冠状动脉闭塞犬注射硝苯地平和地尔硫卓，并通过植入超声长度计监测缺血区和非缺血区心肌的节段性缩短。其他狗用硝酸甘油或硝普赛进行比较。调整所有药物的剂量，使平均主动脉压降低不超过5 mmHg。节段缩短以咬合前控制值的百分比表示。在对照犬（n = 8）中，闭塞后20和80分钟的缺血区缩短平均为-16 +/- 2%和-17 +/- 2%，表明矛盾的伸长。硝苯地平（1 +/- 0.4微克）。公斤。h;n = 8)，治疗前缺血段缩短与对照组无显著差异，但治疗60 min后明显改善，平均为31±4% （P < 0.05）。地尔硫卓（10 +/- 2微克）公斤。h;N = 8)在缺血区缩短方面也有类似的改善。然而，硝酸甘油（177 +/- 20微克）。公斤。h;N = 8)和硝普赛（43 +/- 10微克）。公斤。h;N = 8)未能改善缺血区域的缩短。因此，Ca2+拮抗剂改善缺血区的表现，但硝酸甘油和硝普塞没有。
To characterize the effects of Ca2+ antagonists on the performance of the ischemic myocardium, we administered nifedipine and diltiazem to chloralose-anesthetized dogs with coronary artery occlusion and monitored segmental myocardial shortening in ischemic and nonischemic zones with implanted ultrasonic length gauges. Other dogs were treated with nitroglycerin or nitroprusside for comparison. Dosage of all drugs was adjusted to reduce mean aortic pressure by no more than 5 mmHg. Segmental shortening was expressed as percent of control value before occlusion. In control dogs (n = 8), shortening in ischemic zones 20 and 80 min after occlusion averaged -16 +/- 2% and -17 +/- 2%, indicating paradoxical elongation. With nifedipine (1 +/- 0.4 microgram . kg-1 . h-1; n = 8), shortening of ischemic segments before treatment did not differ from controls, but after 60 min of treatment was markedly improved, averaging 31 +/- 4% (P < 0.05). Diltiazem (10 +/- 2 microgram . kg-1 . h-1; n = 8) produced a similar improvement in shortening in ischemic zones. However, nitroglycerin (177 +/- 20 microgram . kg-1 . h-1; n = 8) and nitroprusside (43 +/- 10 microgram . kg-1 . h-1; n = 8) failed to improve shortening in ischemic regions. Thus, Ca2+ antagonists improved performance in ischemic zones, but nitroglycerin and nitroprusside did not.