Diagnostic utility of FOSB immunohistochemistry in pseudomyogenic hemangioendothelioma and its histological mimics.
Diagnostic utility of FOSB immunohistochemistry in pseudomyogenic hemangioendothelioma and its histological mimics.
复制标题
FOSB 免疫组织化学在假性肌源性血管内皮瘤及其组织学模拟中的诊断效用。
DOI：
10.1186/s13000-016-0530-2
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发表时间：
2016-08-11
影响因子：
2.6
通讯作者：
Hasegawa T
中科院分区：
文献类型：
--
作者：
Sugita S;Hirano H;Kikuchi N;Kubo T;Asanuma H;Aoyama T;Emori M;Hasegawa T
摘要假性肌源性血管内皮瘤是一种罕见的中度恶性血管肿瘤，很少转移，好发于年轻人及儿童的下肢。组织学上，PHE显示嗜酸性梭形细胞和/或上皮样细胞呈束状增殖，显示“假肌原性”形态。免疫组化显示，PHE通常为波形蛋白、细胞角蛋白、CD 31和ERG阳性。我们对27例PHE及其类似组织学病变（包括6例上皮样血管内皮瘤（EHE）、8例血管肉瘤（AS）、4例卡波西肉瘤（KS）和5例上皮样肉瘤（ES））进行了FOSB免疫组化（IHC）检测。此外，我们进行了CAMTA 1的免疫组化，CAMTA 1最近被确定为EHE的有用标记物。我们阐明了FOSB IHC在PHE及其组织学模拟物鉴别诊断中的诊断效用，并检查了FOSB和CAMTA 1 IHC组合在肿瘤鉴别诊断中的有用性。免疫组化显示所有PHE病例中FOSB表达弥漫性强，而其他肿瘤类型显示FOSB表达有限、弱或无表达。所有EHE病例均表现出弥漫性和中度至强烈的CAMTA 1表达。除EHE外，所有肿瘤类型均显示出有限、弱或无CAMTA 1反应性。在当前系列中，弥漫性和强烈的FOSB表达对PHE具有特异性，FOSB IHC是区分PHE及其组织学模拟物的有效工具。此外，FOSB和CAMTA 1 IHC的组合可用于区分PHE和EHE。
Pseudomyogenic hemangioendothelioma (PHE) is an unusual vascular tumor of intermediate malignancy that rarely metastasizes and tends to arise in the lower limbs of young adults and children. Histologically, PHE shows fascicular proliferation of eosinophilic spindle cells and/or epithelioid cells showing “pseudomyogenic” morphology. Immunohistochemically, PHE is usually positive for vimentin, cytokeratin, CD31 and ERG. We examined FOSB immunohistochemistry (IHC) in 27 cases consisting of 4 PHE and its histologic mimics including 6 epithelioid hemangioendotheliomas (EHE), 8 angiosarcomas (AS), 4 Kaposi sarcomas (KS) and 5 epithelioid sarcomas (ES). In addition, we performed IHC of CAMTA1 which has recently been established as a useful marker of EHE. We elucidated the diagnostic utility of FOSB IHC in the differential diagnosis of PHE and its histological mimics and also examined the usefulness of FOSB and CAMTA1 IHC combination in the differential diagnosis of the tumors. IHC revealed diffuse and strong FOSB expression in all PHE cases, while the other tumor types demonstrated limited, weak or no FOSB expression. All EHE cases exhibited diffuse and moderate to strong expression of CAMTA1. All tumor types except for EHE showed limited, weak or no CAMTA1 reactivity. Diffuse and strong FOSB expression was specific for PHE in the current series and FOSB IHC is an effective tool for differentiating between PHE and its histological mimics. Moreover, the combination of FOSB and CAMTA1 IHC is useful for distinguishing PHE from EHE.