Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task
Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task
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DOI：
10.1016/s1053-8119(03)00113-7
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发表时间：
2003-07-01
期刊：
影响因子：
5.7
通讯作者：
Ernst, M
中科院分区：
文献类型：
--
作者：
Bolla, KI;Eldreth, DA;Ernst, M
可卡因滥用者表现出错误的决策，表现为他们无法停止自我毁灭的寻求毒品的行为。眶额皮质（OFC）在决策中起着重要的作用。在这项初步研究中，我们测试了25天的戒断可卡因滥用者在爱荷华州赌博任务（一项决策任务）期间使用PET（15 0）是否显示OFC中标准化脑血流量（rCBF）的改变。这项任务衡量的是权衡短期回报和长期损失的能力。一个控制任务相匹配的感觉运动方面的任务，但不需要决策。与对照组（N = 13）相比，可卡因滥用者（N = 13）在执行爱荷华州赌博任务时右侧OFC的激活程度更高，而右侧背外侧前额叶皮层（DLPFC）和左侧内侧前额叶皮层（MPFC）的激活程度更低。在两组中，更好的爱荷华州赌博任务表现与右侧眶额皮层的更大激活相关。此外，可卡因的使用量（克/周）前25天的强制禁欲与激活左眶额皮层呈负相关。与对照组相比，可卡因滥用者OFC的激活程度更高可能反映了奖励预期的差异，而DLPFC和MPFC的激活程度更低可能反映了计划和工作记忆的差异。这些结果表明，可卡因滥用者表现出持续的功能异常，在前额叶神经网络参与决策，这些影响与可卡因滥用。决策过程中的妥协可能会导致成瘾的发展，并破坏戒烟的努力。(C)2003 Elsevier Science（美国）。All rights reserved.
Cocaine abusers demonstrate faulty decision-making as manifested by their inability to discontinue self-destructive drug-seeking behaviors. The orbitofrontal cortex (OFC) plays an important role in decision-making. In this preliminary study we tested whether 25-day-abstinent cocaine abusers show alterations in normalized cerebral blood flow (rCBF) in the OFC using PET with 15 0 during the Iowa Gambling Task (a decision-making task). This task measures the ability to weigh short-term rewards against long-term losses. A control task matched the sensorimotor aspects of the task but did not require decision-making. Cocaine abusers (N = 13) showed greater activation during performance of the Iowa Gambling Task in the right OFC and less activation in the right dorsolateral prefrontal cortex (DLPFC) and left medial prefrontal cortex (MPFC) compared to a control group (N = 13). Better Iowa Gambling Task performance was associated with greater activation in the right OFC in both groups. Also, the amount of cocaine used (grams/week) prior to the 25 days of enforced abstinence was negatively correlated with activation in the left OFC. Greater activation in the OFC in cocaine abusers compared to a control group may reflect differences in the anticipation of reward while less activation in the DLPFC and MPFC may reflect differences in planning and working memory. These findings suggest that cocaine abusers show persistent functional abnormalities in prefrontal neural networks involved in decision-making and these effects are related to cocaine abuse. Compromised decision-making could contribute to the development of addiction and undermine attempts at abstinence. (C) 2003 Elsevier Science (USA). All rights reserved.