Indocyanine green derived carbon dots with significantly enhanced properties for efficient photothermal therapy
Indocyanine green derived carbon dots with significantly enhanced properties for efficient photothermal therapy
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DOI：
10.1039/d2nr06058b
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发表时间：
2022-12-20
期刊：
影响因子：
6.7
通讯作者：
Peng, Zhili
中科院分区：
文献类型：
--
作者：
Jiang, Yuxiang;Tan, Zhuomin;Peng, Zhili
提出并论证了一种简单有效的全方位提高传统染料吲哚青绿(ICG)性能的方法。具体地说，吲哚青绿衍生碳点(ICGCDs)是由吲哚青绿衍生碳点(ICGCDs)通过简单的水热处理合成的。与ICG相比，ICGCDs表现出显著的热稳定性和抗光漂白性能。此外，它们的光热性能也得到了显著的增强，实现了更宽的功能pH范围，光热转换效率提高了50%，以及优异的光热循环性能。由于这些优异的性质，ICGCDs在体外和体内实验中被证明是有效的近红外生物成像和光热试剂。最令人兴奋的是，这项研究中展示的策略很可能在其他系统中有广泛的应用。
A simple yet effective strategy to enhance the properties of traditional dye indocyanine green (ICG) in all aspects was proposed and demonstrated. Specifically, indocyanine green-derived carbon dots (ICGCDs) were synthesized from ICG via a simple hydrothermal treatment. The ICGCDs exhibited significantly enhanced thermal stability and anti-photobleaching compared to ICG. Furthermore, their photothermal properties were also notably strengthened, in which a wider functional pH range, 50% improvement in photothermal conversion efficiency and superior photothermal cyclability were achieved. Thanks to these superior properties, ICGCDs were demonstrated as efficient NIR bioimaging and photothermal agents in both in vitro and in vivo experiments. Most excitingly, the strategy demonstrated in this study is likely to have broad applications in other systems.