Genetic variants and clinical relevance associated with gestational diabetes mellitus in Chinese women: a case-control study
Genetic variants and clinical relevance associated with gestational diabetes mellitus in Chinese women: a case-control study
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中国女性妊娠期糖尿病相关的遗传变异和临床相关性：病例对照研究。
DOI：
10.1080/14767058.2017.1336225
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发表时间：
2018-01-01
影响因子：
1.8
通讯作者：
Yang, Huixia
中科院分区：
文献类型：
--
作者：
Yan, Jie;Su, Rina;Yang, Huixia
目的：妊娠期糖尿病(GDM)可能与2型糖尿病和肥胖症具有相似的发病机制。在本研究中，我们旨在验证20个已报道的与中国GDM人群中的2型糖尿病和肥胖症相关的基因。方法：研究对象为孕24~28周的20~49岁孕妇，556例孕妇和445例对照。结果：妊娠期糖尿病与rs945508(OR=1.368，95%CI=1.080~1.732，p=0.009)、rs10804591(OR=1.446，95%CI=1.192~1.754，p=0.009)、rs10804591(OR=1.446，95%CI=1.192~1.754，P
Purpose: Gestational diabetes mellitus (GDM) may share similar mechanisms with type 2 diabetes and obesity. In the current study, we aimed to verify twenty genes reported to be associated with type 2 diabetes and obesity in the Chinese GDM population.Methods: Pregnant women aged 20-49years at 24-28 gestational weeks were recruited and 556 cases and 445 controls were enrolled in the study. The genotyping of single nucleotide polymorphisms (SNPs) was performed on peripheral blood samples.Results: We discovered that GDM was associated with rs945508 (OR=1.368, 95% CI=1.080-1.732, p=.009), rs10804591 (OR=1.446, 95% CI=1.192-1.754, p