Biomechanical Phenotyping of Chronic Low Back Pain: Protocol for BACPAC.
Biomechanical Phenotyping of Chronic Low Back Pain: Protocol for BACPAC.
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DOI：
10.1093/pm/pnac163
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发表时间：
2023-08-04
期刊：
影响因子：
3.1
通讯作者：
Bowden, Anton
中科院分区：
文献类型：
--
作者：
Quirk, D. Adam;Johnson, Marit;Anderson, Dennis;Smuck, Matthew;Sun, Ruopeng;Matthew, Robert;Bailey, Jeannie;Marras, William;Bell, Kevin;Darwin, Jessa;Bowden, Anton
生物力学代表了共同的最终输出，所有生物心理社会结构的背部疼痛必须通过，使其成为一个丰富的目标表型。为了利用这一特征，NIH背痛联盟（BACPAC）的几个研究中心开发了生物力学测量和表型分析工具。本文的总体目标是：1）提供生物力学作为表型分析工具的叙述性综述; 2）描述BACPAC中存在的各种工具和结局指标; 3）强调如何利用这些技术与BACPAC中收集的其他数据阐明生物力学与用于表征腰痛（LBP）的其他指标之间的关系。叙述性综述强调了生物力学结果如何区分有无LBP以及LBP的严重程度。它还讨论了生物力学结果如何跟踪LBP的功能改善。此外，我们提出了通过新兴技术可以满足的生物力学结局指标的临床用例。为了满足测量生物力学性能的需求，我们的“结果”部分描述了已经开发并正在BACPAC中使用的技术范围。通过这些技术收集的结果指标将成为在BACPAC进行的纵向和横断面研究的一个组成部分。将这些措施与BACPAC中收集的其他生物心理社会数据联系起来，增加了我们使用生物力学作为理解LBP机制的工具的潜力，表型独特的LBP亚组，并将这些个体与适当的治疗模式相匹配。
Biomechanics represents the common final output through which all biopsychosocial constructs of back pain must pass, making it a rich target for phenotyping. To exploit this feature, several sites within the NIH Back Pain Consortium (BACPAC) have developed biomechanics measurement and phenotyping tools. The overall aims of this article were to: 1) provide a narrative review of biomechanics as a phenotyping tool; 2) describe the diverse array of tools and outcome measures that exist within BACPAC; and 3) highlight how leveraging these technologies with the other data collected within BACPAC could elucidate the relationship between biomechanics and other metrics used to characterize low back pain (LBP). The narrative review highlights how biomechanical outcomes can discriminate between those with and without LBP, as well as among levels of severity of LBP. It also addresses how biomechanical outcomes track with functional improvements in LBP. Additionally, we present the clinical use case for biomechanical outcome measures that can be met via emerging technologies. To answer the need for measuring biomechanical performance, our “Results” section describes the spectrum of technologies that have been developed and are being used within BACPAC. The outcome measures collected by these technologies will be an integral part of longitudinal and cross-sectional studies conducted in BACPAC. Linking these measures with other biopsychosocial data collected within BACPAC increases our potential to use biomechanics as a tool for understanding the mechanisms of LBP, phenotyping unique LBP subgroups, and matching these individuals with an appropriate treatment paradigm.
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