Subthreshold depression may exist on a spectrum with major depressive disorder: Evidence from gray matter volume and morphological brain network
Subthreshold depression may exist on a spectrum with major depressive disorder: Evidence from gray matter volume and morphological brain network
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阈下抑郁症可能存在于重度抑郁症谱系中：来自灰质体积和形态大脑网络的证据
DOI：
10.1016/j.jad.2020.01.135
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发表时间：
2020-04-01
影响因子：
6.6
通讯作者：
Shan, Baoci
中科院分区：
文献类型：
--
作者：
Zhang, Tianhao;Zhao, Bingcong;Shan, Baoci
背景：阈下抑郁症 (StD) 是一种普遍存在的疾病，可能会增加发生重度抑郁症 (MDD) 的风险。然而，StD和MDD之间的关系仍不清楚。方法：总共153名成年受试者，包括53名初治MDD、50名StD和50名健康对照（HC）受试者，接受T1加权磁共振成像扫描，并使用基于体素的形态测量（VBM）定量分析三组之间的灰质体积（GMV）变化。然后，为了捕捉全脑连接特征，我们根据单个 VBM 图像的大脑区域之间的相似性构建了形态学脑网络（MBN），并比较了三组之间的网络连接强度。结果：StD 和 MDD 受试者在眶额皮质和左颞回的 GMV 减少模式相似，尽管 StD 受试者减少的幅度较小。此外，三组之间共有 21 个形态学连接存在显着差异。对于大多数不同的连接（15/21），StD组的连接强度处于MDD和HC组之间的中间位置。 局限性：StD仍然缺乏一致的定义，并且本研究的受试者年龄范围较宽。同时MBN的机制和生物学意义仍有待阐明。结论：这些结果可能支持这样的假设：抑郁症更好地表达为一个谱系，并且StD与MDD存在于一个谱系上。
Background: Subthreshold depression (StD) is a prevalent condition that may increase the risk of incident major depressive disorder (MDD). However, the relationship between StD and MDD remains unclear.Methods: A total of 153 adult subjects, including 53 drug-naive MDD, 50 StD and 50 healthy control (HC) subjects, underwent a T1-weighted magnetic resonance imaging scan, and the gray matter volume (GMV) alterations among the three groups were quantitatively analyzed using voxel-based morphometry (VBM). Then, to capture the whole-brain connectivity characteristics, we constructed morphological brain networks (MBN) based on the similarity among brain regions of individual VBM images and compared the network connection strengths among the three groups.Results: The StD and MDD subjects had similar patterns of GMV reductions in the orbitofrontal cortex and left temporal gyrus, although the magnitude of the reductions was smaller in StD subjects. Moreover, a total of 21 morphological connections were significantly different among the three groups. For the majority of the different connections (15/21), the connection strength of the StD group took an intermediate position between that of the MDD and HC groups.Limitations: There is still a lack of a consistent definition of StD, and the age range of the subjects in this study was wide. Meanwhile the mechanisms and biological significance of the MBN remains to be clarified.Conclusions: These results may support the hypothesis that depression is better expressed as a spectrum and that StD exists on a spectrum with MDD.