Health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs)
Health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs)
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DOI：
10.1016/s0160-4120(03)00106-5
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发表时间：
2003-09-01
影响因子：
11.8
通讯作者：
Diliberto, JJ
中科院分区：
文献类型：
--
作者：
Birnbaum, LS;Staskal, DF;Diliberto, JJ
本文综述了多溴代二苯并对二恶英（PBDD）和二苯并呋喃（PBDF）对健康影响的科学研究现状。虽然已经发表了数千篇关于2，3，7，8-四氯二苯并对二恶英和相关多氯二苯并二恶英（PCDD）和二苯并呋喃（PCDF）对健康影响的文章，但对溴化和混合氯/溴同系物的了解甚少。现有文献表明，溴化化合物的毒性特征与其氯化同系物相似。然而，只有在暴露情景确实存在的情况下，调查健康影响的进一步研究才会有用。目前的接触数据极为有限，在评估这些化学品的潜在风险方面存在重大数据缺口。溴化阻燃剂使用的迅速增加提高了对多溴二苯并对二恶英/多溴二苯并呋喃的环境关切程度，因为人类以及野生动物接触溴化二恶英和呋喃的情况可能会随着其使用而增加。出版社：Elsevier Science Ltd
This article reviews the state of the science regarding the health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs). While thousands of articles have been published on the health effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related polychlorinated dibenzodioxins (PCDDs) and dibenzofurans (PCDFs), little is know about the brominated and mixed chloro/bromo homologs. Available literature suggests that brominated compounds have similar toxicity profiles to their chlorinated homologs. However, further research investigating health effects will only be useful if exposure scenarios truly exist. Current exposure data is extremely limited, posing a major data gap in assessing potential risk of these chemicals. The rapid increase in the use of brominated flame retardants has raised the level of environmental concern regarding PBDDs/PBDFs as it is likely that human, as well as wildlife, exposure to brominated dioxins and furans will increase with their use. Published by Elsevier Science Ltd.