The omega-3 fatty acids EPA and DHA decrease plasma F2-isoprostanes: Results from two placebo-controlled interventions
The omega-3 fatty acids EPA and DHA decrease plasma F2-isoprostanes: Results from two placebo-controlled interventions
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DOI：
10.3109/10715762.2010.492830
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发表时间：
2010-09-01
影响因子：
3.3
通讯作者：
Mori, Trevor A.
中科院分区：
文献类型：
--
作者：
Mas, Emilie;Woodman, Richard J.;Mori, Trevor A.
Omega-3 (omega 3) 脂肪酸，特别是二十碳五烯酸 (EPA) 和二十二碳六烯酸 (DHA)，可预防心血管疾病。尽管有这些好处，但人们仍然担心（omega 3 脂肪酸可能会增加脂质过氧化）。之前的研究表明，人体补充 w3 脂肪酸后，尿液中的 F-2-异前列腺素 (F-2-IsoPs) 会减少。现在已确定补充 EPA 或 DHA 是否会影响血浆 F-2-IsoPs。在两项为期 6 周的安慰剂对照干预措施中，研究 A：超重、血脂异常男性；研究 B：治疗高血压型2 名糖尿病患者被随机分配至每日 4 g EPA、DHA 组，与橄榄油组相比，EPA（研究 A 中为 24%，研究 B 中为 19%）和 DHA（研究 A 中为 14%，研究 B 中为 23%）干预后血浆 F2-IsoP 显着降低。两项研究中均未在血浆中观察到 F-3- 和 F-4-IsoP。 这些结果表明，根据人体血浆和尿液中的测量结果，EPA 和 DHA 可减少体内氧化应激。
Omega-3 (omega 3) fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), protect against cardiovascular disease. Despite these benefits, concern remains that (omega 3 fatty acids may increase lipid peroxidation. It has previously been shown that urinary F-2-isoprostanes (F-2-IsoPs) were reduced following w3 fatty acid supplementation in humans. It is now determined whether EPA or DHA supplementation affects plasma F-2-IsoPs. In two 6-week placebo-controlled interventions, Study A: overweight, dyslipidaemic men; and Study B: treated-hypertensive Type 2 diabetic, patients were randomized to 4 g daily EPA, DHA. Post-intervention plasma F-2-IsoPs were significantly reduced by EPA (24% in Study A, 19% in Study B) and by DHA (14% in Study A, 23% in Study B) relative to the olive oil group. The fall in plasma F2-lsoPs was not altered in analyses that corrected for changes in plasma arachidonic acid, which was reduced with EPA and DHA supplementation. Neither F-3-nor F-4-IsoPs were observed in plasma in both studies. These results show that in humans, EPA and DHA reduce in vivo oxidant stress as measured in human plasma and urine.