Metyrapone Administration Reduces the Strength of an Emotional Memory Trace in a Long-Lasting Manner
Metyrapone Administration Reduces the Strength of an Emotional Memory Trace in a Long-Lasting Manner
复制标题
DOI：
10.1210/jc.2011-0226
复制
发表时间：
2011-08-01
影响因子：
5.8
通讯作者：
Lupien, Sonia J.
中科院分区：
文献类型：
--
作者：
Marin, Marie-France;Hupbach, Almut;Lupien, Sonia J.
内容：最近已经证明，记忆提取的过程作为一种再激活机制，由此在提取过程中被再激活的记忆痕迹再次对环境或药理学操作的修改敏感。最近的研究表明，糖皮质激素（GCs）具有调节记忆提取过程的能力。这表明，GC可能是一个有趣的途径，调查方面的减少emotional memory.Objective：本研究评估是否药理学降低GC水平，诱导甲吡酮，一个有效的抑制剂GC分泌，会影响检索的情绪和中性信息在一个急性和/或长期持久的方式。设计，设置，参与者，和干预：为此，在编码具有中性和情感片段的幻灯片放映后3天，向年轻的正常参与者施用1 X 750 mg剂量的甲吡酮、2 X 750 mg剂量的甲吡酮或安慰剂。实验在一所大学和一家医院进行。主要结果测量：治疗后和4 d后评估记忆表现。结果：结果显示，双倍剂量甲吡酮组的情绪信息提取严重受损，4 d后这种效果仍然存在，此时组间GC水平没有差异。这些结果表明，通过甲吡酮给药降低GC水平是以持久方式降低情绪记忆强度的有效方法。（临床内分泌代谢杂志96：E1221-E1227，2011）
Context: It has recently been demonstrated that the process of memory retrieval serves as a reactivation mechanism whereby the memory trace that is reactivated during retrieval is once again sensitive to modifications by environmental or pharmacological manipulations. Recent studies have shown that glucocorticoids (GCs) have the capacity to modulate the process of memory retrieval. This suggests that GCs could be an interesting avenue to investigate with regard to reduction of emotional memory.Objective: The current study assessed whether a pharmacological decrease in GC levels, induced by metyrapone, a potent inhibitor of GC secretion, would affect retrieval of emotional and neutral information in an acute and/or long-lasting manner.Design, Setting, Participants, and Intervention: To do so, 1 X 750 mg dose of metyrapone, 2 X 750 mg dose of metyrapone, or placebo was administered to young normal participants 3 d after the encoding of a slide show having neutral and emotional segments. The experiment took place in a university and a hospital setting.Main Outcome Measure: Memory performance was assessed after treatment and 4 d later.Results: Results showed that retrieval of emotional information was acutely impaired in the double-dose metyrapone group and that this effect was still present 4 d later, when GC levels were not different between groups.Conclusions: These results show that decreasing GC levels via metyrapone administration is an efficient way to reduce the strength of an emotional memory in a long-lasting manner. (J Clin Endocrinol Metab 96: E1221-E1227, 2011)