Enzymatically Triggered Self-Assembly of Block Copolymers
Enzymatically Triggered Self-Assembly of Block Copolymers
复制标题
DOI：
10.1021/ja9060917
复制
发表时间：
2009-10-07
影响因子：
15
通讯作者：
Hawker, Craig J.
中科院分区：
文献类型：
--
作者：
Amir, Roey J.;Zhong, Sheng;Hawker, Craig J.
乙烯基单体与可裂解酶底物的聚合已被证明可产生水溶性双亲水性嵌段共聚物，该共聚物在二嵌段共聚物的酶促活化后变得两亲性并自组装成胶体纳米结构。通过酶反应改变聚合物材料的化学和物理特性的能力为新颖且令人兴奋的应用开辟了道路，例如酶触发的表面活化和以高度受控的方式在体内形成纳米结构。
The polymerization of vinyl monomers with cleavable enzymatic substrates has been shown to lead to water-soluble double-hydrophilic block copolymers which, upon enzymatic activation of the diblock copolymers, become amphiphilic and undergo Self-assembly into colloidal nanostructures. The ability to change the chemical and physical characteristics of polymeric materials by an enzymatic reaction opens the way for novel and exciting applications such as enzymatic-triggered activation of surfaces and formation of nanostructures in vivo in a highly controlled manner.