Why Evolve Reliance on the Microbiome for Timing of Ontogeny?
Why Evolve Reliance on the Microbiome for Timing of Ontogeny?
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DOI：
10.1128/mbio.01496-19
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发表时间：
2019-09-01
期刊：
影响因子：
6.4
通讯作者：
Koskella, Britt
中科院分区：
文献类型：
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作者：
Metcalf, C. Jessica E.;Henry, Lucas P.;Koskella, Britt
生活史事件的时间安排对健康有着重要的影响。自20世纪50年代以来，研究人员一直在结合第一性原理和数据来预测生活史转变的最佳时机。最近，一个惊人的谜团浮出水面。这样的转变可以由生命之树的一个完全不同的分支塑造：微生物群中的物种。使用进化论中的可测试预测来探索这些相互作用，可以解释宿主-微生物组整合的生活史是否以及如何进化和维持。除了推进基础科学之外，这项研究计划还可能产生重要的应用。在微生物组工程的时代，了解导致微生物区系信号形成个体发育的背景可以为通过操纵植物对胁迫环境的反应来提高农业产量或通过影响媒介效率来减少病原体传播提供新的机制。我们结合理论和证据来阐明微生物组依赖的个体发生计时(MiDOT)存在的基本问题，以推动对这一新兴主题的研究。
The timing of life history events has important fitness consequences. Since the 1950s, researchers have combined first principles and data to predict the optimal timing of life history transitions. Recently, a striking mystery has emerged. Such transitions can be shaped by a completely different branch of the tree of life: species in the microbiome. Probing these interactions using testable predictions from evolutionary theory could illuminate whether and how host-microbiome integrated life histories can evolve and be maintained. Beyond advancing fundamental science, this research program could yield important applications. In an age of microbiome engineering, understanding the contexts that lead to microbiota signaling shaping ontogeny could offer novel mechanisms for manipulations to increase yield in agriculture by manipulating plant responses to stressful environments, or to reduce pathogen transmission by affecting vector efficiency. We combine theory and evidence to illuminate the essential questions underlying the existence of microbiome-dependent ontogenetic timing (MiDOT) to fuel research on this emerging topic.