S-nitrosohaemoglobin: A dynamic activity of blood involved in vascular control
S-nitrosohaemoglobin: A dynamic activity of blood involved in vascular control
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DOI：
10.1038/380221a0
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发表时间：
1996-03-21
期刊：
影响因子：
64.8
通讯作者：
Stamler, JS
中科院分区：
文献类型：
--
作者：
Jia, L;Bonaventura, C;Stamler, JS
存在一个动态循环，其中当红细胞被氧化时，血红蛋白在肺中被S-亚硝基化，并且NO基团在动脉-静脉运输期间被释放。S-亚硝基血红蛋白的血管活性是由S-亚硝基硫醇的红细胞输出促进的。这些发现突出了新发现的血红蛋白的变构和电子特性，这些特性似乎参与了血压的控制，并可能有助于有效地向组织输送氧气。S-亚硝基血红蛋白在NO相关活动的转导中的作用可能具有治疗应用。
A dynamic cycle exists in which haemoglobin is S-nitrosylated in the lung when red blood cells are oxygenated, and the NO group is released during arterial-venous transit. The vasoactivity of S-nitrosohaemoglobin is promoted by the erythrocytic export of S-nitrosothiols. These findings highlight newly discovered allosteric and electronic properties of haemoglobin that appear to be involved in the control of blood pressure and which may facilitate efficient delivery of oxygen to tissues. The role of S-nitrosohaemoglobin in the transduction of NO-related activities may have therapeutic applications.