B7-H3 Over Expression in Prostate Cancer Promotes Tumor Cell Progression
B7-H3 Over Expression in Prostate Cancer Promotes Tumor Cell Progression
复制标题
B7-H3 在前列腺癌中过度表达可促进肿瘤细胞进展。
DOI：
10.1016/j.juro.2011.04.103
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发表时间：
2011-09-01
影响因子：
6.6
通讯作者：
Hou, Jianquan
中科院分区：
文献类型：
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作者：
Yuan, Hexing;Wei, Xuedong;Hou, Jianquan
目的：我们比较了B7-H3在良性前列腺增生和前列腺癌组织标本中的表达，并利用RNA干扰技术检测了B7-H3低表达对PC-3人前列腺癌细胞系的影响。利用RNA干扰技术建立低表达B7-H3的PC-3细胞系，研究B7-H3对PC-3细胞增殖、粘附、迁移和侵袭的影响。前列腺癌组组织样本中的B7-H3显著高于良性前列腺增生组（平均值± SEM 174.73 ± 56.80 vs 82.69 ± SEM 46.19纳克/克，p
Purpose: We compared B7-H3 expression in benign prostatic hyperplasia and prostate cancer tissue specimens, and determined the effects of low B7-H3 expression on the PC-3 human prostate cancer cell line using RNA interference.Materials and Methods: B7-H3 expression in prostate specimens was determined by enzyme-linked immunosorbent assay. A PC-3 cell line with low B7-H3 expression was established by RNA interference to investigate the effect of B7-H3 on cell proliferation, adhesion, migration and invasion in vitro.Results: B7-H3 in tissue samples was significantly higher in the prostate cancer group than in the benign prostatic hyperplasia group (mean +/- SEM 174.73 +/- 56.80 vs 82.69 +/- 46.19 ng/gm, p