Prevalence of Essential Tremor in a Multiethnic, Community-Based Study in Northern Manhattan, New York, NY
Prevalence of Essential Tremor in a Multiethnic, Community-Based Study in Northern Manhattan, New York, NY
复制标题
DOI：
10.1159/000195691
复制
发表时间：
2009-01-01
影响因子：
5.7
通讯作者：
Andrews, Howard F.
中科院分区：
文献类型：
--
作者：
Louis, Elan D.;Thawani, Sujata P.;Andrews, Howard F.
背景：我们的目标是：(1) 在美国纽约州曼哈顿北部的一项基于社区的研究中估计特发性震颤 (ET) 的患病率； (2) 比较不同种族群体的患病率，(3) 提供最年长老年人的患病率估计值。方法：本研究不依赖筛选问卷。相反，作为现场神经学评估的一部分，每个参与者都制作了几个笔迹样本，并根据这些样本进行 ET 诊断。结果：共有 1,965 名参与者（76.7 +/- 8 6.9 岁，范围 = 66-102 岁）； 108 人患有 ET [5.5%，95% 置信区间 (CI) = 4.5-6.5%]。 ET 的发生率与西班牙裔与白人种族的发生率密切相关[比值比 (OR) = 2.19，95% CI = 1.03-4.64，p = 0.04] 和年龄（OR = 1.14，95% CI = 1.03-1.26，p = 0.01），即年龄每增加 1 年，发生 ET 的发生率就会增加14%。最年长的老年人（年龄≥95岁）的患病率达到21.7%。结论：本研究报告 ET 患病率存在显着的种族差异。 ET 的患病率总体较高（5.5%），并且随着年龄的增长而显着上升，因此在年龄最大的老年人中，超过五分之一的人患有这种疾病。版权所有 (C) 2009 S. Karger AG，巴塞尔
Background: Our aims were to: (1) estimate the prevalence of essential tremor (ET) in a community-based study in northern Manhattan, New York, N.Y., USA; (2) compare prevalence across ethnic groups, and (3) provide prevalence estimates for the oldest old. Methods: This study did not rely on a screening questionnaire. Rather, as part of an in-person neurological evaluation, each participant produced several handwriting samples, from which ET diagnoses were assigned. Results: There were 1,965 participants (76.7 +/- 8 6.9 years, range = 66-102 years); 108 had ET [5.5%, 95% confidence interval (CI) = 4.5-6.5%]. Odds of ET were robustly associated with Hispanic ethnicity versus white ethnicity [odds ratio (OR) = 2.19, 95% CI = 1.03-4.64, p = 0.04] and age (OR = 1.14, 95% CI = 1.03-1.26, p = 0.01), i.e. with every 1 year advance in age, the odds of ET increased by 14%. Prevalence reached 21.7% among the oldest old (age >= 95 years). Conclusions: This study reports a significant ethnic difference in the prevalence of ET. The prevalence of ET was high overall (5.5%) and rose markedly with age so that in the oldest old, more than 1 in 5 individuals had this disease. Copyright (C) 2009 S. Karger AG, Basel