BEHAVIORAL SIMILARITIES BETWEEN MOTHER RATS AND BENZODIAZEPINE-TREATED NON-MATERNAL ANIMALS
BEHAVIORAL SIMILARITIES BETWEEN MOTHER RATS AND BENZODIAZEPINE-TREATED NON-MATERNAL ANIMALS
复制标题
DOI：
10.1007/bf00432226
复制
发表时间：
1985-01-01
影响因子：
3.4
通讯作者：
SELART, ME
中科院分区：
文献类型：
--
作者：
HANSEN, S;FERREIRA, A;SELART, ME
哺育大窝的母鼠嗜食，对同种动物具有攻击性，并且表现出比非母性动物更少的冰冻行为。这些自然发生的适应类似于未交配的大鼠在接受苯二氮卓类药物治疗后产生的适应，这表明母鼠和接受苯二氮卓类药物治疗的未交配大鼠的大脑中存在一种共同的神经化学变化。根据这一假设，我们发现3种功能性苯二氮卓类拮抗剂(FG 7142[N''-甲基- β。（-carboline-3-carboxamide）戊烯四氮，咖啡因)减少了哺乳母鼠的食物摄入量，降低了攻击性，并加强了冷冻。这些心理药理学观察支持了GABA神经传递在母性期间增强的观点。
Mother rats nursing large litters are hyperphagic, aggressive towards conspecifics, and show less freezing behavior than non-maternal animals. These naturally occurring adaptations resemble those elicited by benzodiazepine treatment in virgin rats, indicating a common neurochemical change in the brains of mother rats and benzodiazepine-treated virgins. In line with this hypothesis, it was found that 3 functional benzodiazepine antagonists (FG 7142[N''-methyl-.beta.-carboline-3-carboxamide] pentylenetetrazol, caffeine) decreased food intake, lowered aggression and strenghtened freezing in lactating mother rats. These psychopharmacological observations support the idea that GABA neurotransmission is enhanced during motherhood in the rat.