Application of directed orthometalation toward the synthesis of aryl siloxanes.
Application of directed orthometalation toward the synthesis of aryl siloxanes.
复制标题
定向邻位金属化在芳基硅氧烷合成中的应用。
DOI：
10.1021/jo0492057
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
DeShong,Philip
中科院分区：
文献类型：
--
作者：
Seganish,WMichael;DeShong,Philip
选择邻位取代的芳基硅氧烷已经通过定向邻位取代反应制备。这些硅氧烷可以通过使用不同选择的邻位导向基团和亲电子硅氧烷衍生物以高产率和纯度制备。该硅氧烷用于与芳基溴的钯催化的交叉偶联反应中，以良好至优异的产率生成不对称邻位取代的联芳基。
A selection of ortho-substituted aryl siloxanes have been prepared by directed orthometalation protocols. These siloxanes can be prepared in high yields and purity by use of a diverse selection of ortho-directing groups and electrophilic siloxane derivatives. The siloxanes are employed in palladium-catalyzed cross-coupling reactions with aryl bromides to generate unsymmetrical ortho-substituted biaryls in good to excellent yields.