Evaluation of optimal water fluoridation on the incidence and skeletal distribution of naturally arising osteosarcoma in pet dogs.
Evaluation of optimal water fluoridation on the incidence and skeletal distribution of naturally arising osteosarcoma in pet dogs.
复制标题
最佳水氟化对宠物狗自然发生的骨肉瘤的发病率和骨骼分布的评估。
DOI：
10.1111/vco.12188
复制
发表时间：
2017
影响因子：
2.1
通讯作者：
King,AM
中科院分区：
文献类型：
--
作者：
Rebhun,RB;Kass,PH;Kent,MS;Watson,KD;Withers,SS;Culp,WTN;King,AM
在实验室动物和流行病学人类研究的实验毒理学研究报告了水氟化和骨肉瘤（OSA）之间的可能关联。为了进一步探索这种可能性，由加州大学戴维斯分校兽医教学医院使用基于主人住所的水氟化生态数据对个体犬进行了病例对照研究。病例组包括2008-2012年间诊断为OSA的161只狗。两个癌症对照组包括在同一时期诊断为淋巴瘤（LSA）或血管肉瘤（HSA）的狗（分别为n= 134和n = 145）。患有OSA的狗并没有比患有LSA或HSA的狗更有可能生活在水中氟最优化的地区。对OSA患者的进一步分析也显示，OSA患者的年龄或骨骼分布与氟化物状况无显著差异。总之，这些分析不支持饮用水的最佳氟化有助于犬自然发生OSA的假设。
Experimental toxicological studies in laboratory animals and epidemiological human studies have reported a possible association between water fluoridation and osteosarcoma (OSA). To further explore this possibility, a case‐control study of individual dogs evaluated by the UC Davis Veterinary Medical Teaching Hospital was conducted using ecologic data on water fluoridation based on the owner's residence. The case group included 161 dogs with OSA diagnosed between 2008–2012. Two cancer control groups included dogs diagnosed with lymphoma (LSA) or hemangiosarcoma (HSA) during the same period (n= 134 andn= 145, respectively). Dogs with OSA were not significantly more likely to live in an area with optimized fluoride in the water than dogs with LSA or HSA. Additional analyses within OSA patients also revealed no significant differences in age, or skeletal distribution of OSA cases relative to fluoride status. Taken together, these analyses do not support the hypothesis that optimal fluoridation of drinking water contributes to naturally occurring OSA in dogs.