Comparison of Unilateral and Bilateral Complex Finger Tapping-Related Activation in Premotor and Primary Motor Cortex
Comparison of Unilateral and Bilateral Complex Finger Tapping-Related Activation in Premotor and Primary Motor Cortex
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DOI：
10.1002/hbm.20610
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发表时间：
2009-04-01
影响因子：
4.8
通讯作者：
Phillips, Micheal D.
中科院分区：
文献类型：
--
作者：
Horenstein, Craig;Lowe, Mark J.;Phillips, Micheal D.
16名健康的右撇子受试者进行了一项复杂的手指敲击任务，该任务广泛激活了运动和运动前区，包括初级运动（M1），腹侧运动前区（PMv）和背侧运动前区（PMd）皮层。仅用右手、仅用左手和双手同时执行该任务。通过使用MRI兼容手套监测手指运动来控制行为表现和镜像运动的可能性。使用空间归一化的ROI从人类运动区模板（HMAT），比较的空间范围和位置的激活在所有三个任务之间的左，右运动区。在单侧右、左手叩击时，所有受试者均出现同侧中央前回激活，主要集中在PMv和PMd。同侧M1激活不太一致，并在M1内向前移动，朝向M1和运动前皮质的边界。在对侧和双侧任务中，同侧激活区域也被激活。总体而言，M1/PMd/PMv中83%/70%/58%的同侧激活体素在对侧和双侧敲击期间也被激活。空间重叠激活体素的平均百分比信号变化是相似的PMv和PMd之间的所有三个任务。然而，在同侧轻敲期间，与对侧或双侧轻敲相比，空间重叠的M1激活的平均信号变化百分比显著更小。结果表明，同侧的功能磁共振成像激活在单侧运动任务可能不是抑制性的，而是可能反映了双边网络的一部分，参与规划和/或执行的同侧的手攻。《脑图谱》30：1397-1412，2009年。(C)2008 Wiley-Liss，Inc.
Sixteen healthy, right-handed subjects performed a complex finger-tapping task that broadly activates the motor and premotor regions, including primary motor (M1), ventral premotor (PMv), and dorsal premotor (PMd) cortex. This task was performed with the right hand only, left hand only and both hands Simultaneously. Behavioral performance and the possibility of mirror movements were controlled through the use of MRI-compatible gloves to monitor finger movements. Using spatially normalized ROIs from the Human Motor Area Template (HMAT), comparisons were made of the spatial extent and location of activation in the left and right motor regions between all three tasks. During Unilateral right and left hand tapping, ipsilateral precentral gyrus activation occurred in all subjects, mainly in the PMv and PMd. Ipsilateral M1 activation was less consistent and shifted anteriorly within M1, towards the border of M1 and premotor cortex. Regions of ipsilateral activation were also activated during contralateral and bilateral tasks. Overall, 83%/70%,/58%, of the ipsilaterally activated voxels in M1/PMd/PMv were also activated during contralateral and bilateral tapping. The mean percent signal change of spatially overlapping activated voxels was similar in PMv and PMd between all three tasks. However, the mean percent signal change of spatially overlapping M1 activation was significantly less during ipsilateral tapping compared with contra- or bilateral tapping. Results suggest that the ipsilateral fMRI activation in unilateral motor tasks may not be inhibitory in nature, but rather may reflect part of a bilateral network involved in the planning and/or execution of tapping in the ipsilateral hand. Hum Brain Mapp 30:1397-1412, 2009. (C) 2008 Wiley-Liss, Inc.