Feasibility and efficacy of cognitive telerehabilitation in early Alzheimer's disease: a pilot study
Feasibility and efficacy of cognitive telerehabilitation in early Alzheimer's disease: a pilot study
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DOI：
10.2147/cia.s68145
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发表时间：
2014-01-01
影响因子：
3.6
通讯作者：
Cagnin, Annachiara
中科院分区：
文献类型：
--
作者：
Jelcic, Nela;Agostini, Michela;Cagnin, Annachiara
背景资料：本研究比较了通过电信技术进行词汇语义刺激的效果（LSS-tele）与现场LSS方法：对27例早期阿尔茨海默病患者进行了LSS-直接认知治疗（LSS-direct）和非结构化认知治疗（UCS）的对比研究（简易精神状态检查[MMSE]> 26/30）分为三组：7名患者接受了LSS远程治疗，10名患者接受了标准LSS直接干预，10名参与者接受了UCS作为对照条件。干预治疗包括每周两次的LSS（通过电话会议或面对面，取决于小组分配）或UCS练习，在整个3个月的时间内对小组进行管理。主要观察指标为整体认知能力、语言能力和记忆功能的变化。次要结果的措施是注意力，工作记忆，执行功能，视觉空间能力tests.Results的变化：平均MMSE评分显着改善，在LSS-远程和LSS-直接治疗; LSS-远程改善语言能力，语音和语义，并稳定延迟言语情景记忆与LSS-直接干预后的改善性能和记忆力下降在对照组观察。结论：临床应用电信技术对老年神经退行性认知障碍患者进行认知康复是可行的，并可改善整体认知能力。技术方面，以改善交付的功效可能会进一步提高其对特定领域的认知能力的影响。
Background: This pilot study compared the effects of lexical-semantic stimulation through telecommunication technology (LSS-tele) with in-person LSS (LSS-direct) and unstructured cognitive treatment (UCS) in patients with early Alzheimer's disease.Methods: Twenty-seven patients with Alzheimer's disease in the very early stage (Mini-Mental State Examination [MMSE]>26/30) were divided into three groups: seven patients received LSS-tele treatment, ten received standard LSS-direct intervention, and ten participants underwent UCS as control condition. Intervention treatments consisted of two weekly sessions of LSS (through teleconference or face to face depending on group assignment) or UCS exercises administered to small groups throughout a 3-month period. The main outcome measures were changes of global cognitive performance, language abilities, and memory function. Secondary outcome measures were changes in attention, working memory, executive functions, and visual-spatial abilities tests.Results: The mean MMSE score improved significantly in LSS-tele and LSS-direct treatments; LSS-tele improved language abilities, both phonemic and semantic, and stabilized delayed verbal episodic memory with respect to an improved performance after the LSS-direct intervention and to a memory decline observed in the control group. Improvement was not achieved in any neuropsychological test score after UCS.Conclusion: Clinical application of telecommunication technology to cognitive rehabilitation of elderly patients with neurodegenerative cognitive impairment is feasible and may improve global cognitive performance. Technical aspects to ameliorate efficacy of delivery may further improve its impact on domain-specific cognitive abilities.