Spatially segregated feedforward and feedback neurons support differential odor processing in the lateral entorhinal cortex
Spatially segregated feedforward and feedback neurons support differential odor processing in the lateral entorhinal cortex
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DOI：
10.1038/nn.4303
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发表时间：
2016-07-01
影响因子：
25
通讯作者：
Monyer, Hannah
中科院分区：
文献类型：
--
作者：
Leitner, Frauke C.;Melzer, Sarah;Monyer, Hannah
侧向肾上腺皮质（LEC）将嗅觉信息从嗅球计算并传输到海马。在这里，我们建立了与上游和下游大脑区域的LEC连接性，以了解LEC如何处理嗅觉信息。我们报告说，在第二层（LII）中，reelin和calbindin阳性（RE+和CB+）神经元构成了两种主要的兴奋性细胞类型，这些细胞类型在电生理学上与众不同，并且连接了差异。 RE+神经元将信息传达给海马，而CB+神经元将信息投射到嗅觉皮层和嗅球。体内钙成像表明，与CB+神经元和GABA能神经元相比，RE+神经元对特定气味的选择性更高。在人群水平上，RE+的气味歧视明显好于CB+神经元，而GABA能神经元最低。因此，我们在LII中鉴定出在解剖学和功能上不同的神经元亚群中，这些亚群在气味处理过程中差异化参与进料和反馈信号。
The lateral entorhinal cortex (LEC) computes and transfers olfactory information from the olfactory bulb to the hippocampus. Here we established LEC connectivity to upstream and downstream brain regions to understand how the LEC processes olfactory information. We report that, in layer II (LII), reelin- and calbindin-positive (RE+ and CB+) neurons constitute two major excitatory cell types that are electrophysiologically distinct and differentially connected. RE+ neurons convey information to the hippocampus, while CB+ neurons project to the olfactory cortex and the olfactory bulb. In vivo calcium imaging revealed that RE+ neurons responded with higher selectivity to specific odors than CB+ neurons and GABAergic neurons. At the population level, odor discrimination was significantly better for RE+ than CB+ neurons, and was lowest for GABAergic neurons. Thus, we identified in LII of the LEC anatomically and functionally distinct neuronal subpopulations that engage differentially in feedforward and feedback signaling during odor processing.