Circulating levels of cytokines during pregnancy: thrombopoietin is elevated in miscarriage
Circulating levels of cytokines during pregnancy: thrombopoietin is elevated in miscarriage
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DOI：
10.1016/j.fertnstert.2007.05.046
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发表时间：
2008-06-01
影响因子：
6.7
通讯作者：
Chegini, Nasser
中科院分区：
文献类型：
--
作者：
Whitcomb, Brian W.;Schisterman, Enrique F.;Chegini, Nasser
目的：使用流产报告前收集的血清样本评估细胞因子水平与流产风险相关的假设。设计：巢式病例对照研究。设置：来自佛罗里达大学多中心围产期合作项目的生物标本，白细胞介素（IL）-1受体拮抗剂、IL-1 β、IL-4、IL-6、干扰素（IFN）-γ、肿瘤坏死因子（TNF）-α的实验室评估，血小板生成素（TPO）和粒细胞集落刺激因子（G-CSF）。患者：流产病例（n = 439）与对照组（n = 373）在样本采集时的胎龄相匹配。干预：无。主要结局指标：流产。结果：流产风险增加与TPO升高有关（校正比值比[OR] 1.16，95%置信区间[CI] 1.00-1.36）和G-CSF降低（校正OR 0.78，95% CI 0.64-0.95）。当分析仅限于流产前35天以上采集的样本时，未观察到G-CSF的作用（校正OR 0.96，95%CI 0.72-1.28），而与较高TPO相关的风险增加仍然存在。
Objective: To evaluate the hypothesis that cytokine levels are associated with miscarriage risk using serum samples collected before report of miscarriage.Design: A nested case-control study.Setting: Biospecimens from the multisite Collaborative Perinatal Project, University of Florida, laboratory assessment of interleukin (IL)-1 receptor antagonist, IL-1 beta, IL-4, IL-6, Interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, thrombopoietin (TPO), and granulocyte colony-stimulating factor (G-CSF).Patient(s): Cases of miscarriage (n = 439) were matched to control,, (n = 373) by gestational age at sample collection.Intervention(s): None.Main Outcome Measure(s): Miscarriage.Result(s): Increased risk of miscarriage was associated with elevated TPO (adjusted odds ratio [OR] 1.16, 95% confidence interval [CI] 1.00-1.36) and decreased G-CSF (adjusted OR 0.78, 95% Cl 0.64-0.95). When analysis was restricted to samples collected more than 35 days before miscarriage, the effect of G-CSF was not observed (adjusted OR 0.96, 95% Cl 0.72-1.28), whereas increased risk related to higher TPO remained.Conclusion(s): Circulating levels of TPO may be associated with increased risk of miscarriage.