The impact of histone post-translational modifications in neurodegenerative diseases.
The impact of histone post-translational modifications in neurodegenerative diseases.
复制标题
组蛋白翻译后修饰在神经退行性疾病中的影响。
DOI：
10.1016/j.bbadis.2018.10.019
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发表时间：
2019-08-01
期刊：
影响因子：
--
通讯作者：
Torrente MP
中科院分区：
文献类型：
--
作者：
Cobos SN;Bennett SA;Torrente MP
仅在美国，每年就有5000多人死于神经退行性疾病。许多神经性疾病的治疗方法尚未被发现。大多数肌萎缩性侧索硬化症（ALS）、额颞叶痴呆（FTD）和帕金森病（PD）病例没有已知的遗传基础。因此，很明显，当代遗传方法未能解释ALS/FTD和PD的病因学。最近的研究探索了表观遗传机制在疾病发展中的潜在作用。表观遗传学包括基因利用的可遗传变化，这些变化不是来自基因组的变化。一个主要的表观遗传机制涉及组蛋白的翻译后修饰。增加对神经退行性疾病的表观基因组景观的了解不仅会进一步加深我们对疾病病理的理解，而且还会导致能够阻止其进展的治疗方法的发展。在这里，我们回顾了组蛋白翻译后修饰与ALS、FTD、PD和几种共济失调之间关系的最新进展。
Every year, neurodegenerative disorders take more than 5,000 lives in the US alone. Cures have not yet been found for many of the multitude of neuropathies. The majority of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Parkinson’s disease (PD) cases have no known genetic basis. Thus, it is evident that contemporary genetic approaches have failed to explain the etiology or etiologies of ALS/FTD and PD. Recent investigations have explored the potential role of epigenetic mechanisms in disease development. Epigenetics comprises heritable changes in gene utilization that are not derived from changes in the genome. A main epigenetic mechanism involves the post-translational modification of histones. Increased knowledge of the epigenomic landscape of neurodegenerative diseases would not only further our understanding of the disease pathologies, but also lead to the development of treatments able to halt their progress. Here, we review recent advances on the association of histone post-translational modifications with ALS, FTD, PD and several ataxias.
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影响因子：
5
作者：
Chen K;Bennett SA;Rana N;Yousuf H;Said M;Taaseen S;Mendo N;Meltser SM;Torrente MP
通讯作者：
Torrente MP
影响因子：
2.4
作者：
Akbar, Umar;Ashizawa, Tetsuo
通讯作者：
Ashizawa, Tetsuo
影响因子：
5.3
作者：
Aulas A;Vande Velde C
通讯作者：
Vande Velde C
影响因子：
168.9
作者：
Chartier-Harlin, MC;Kachergus, J;Destée, A
通讯作者：
Destée, A
影响因子：
16.2
作者：
Alami NH;Smith RB;Carrasco MA;Williams LA;Winborn CS;Han SSW;Kiskinis E;Winborn B;Freibaum BD;Kanagaraj A;Clare AJ;Badders NM;Bilican B;Chaum E;Chandran S;Shaw CE;Eggan KC;Maniatis T;Taylor JP
通讯作者：
Taylor JP