Cellular plasticity within the pancreas--lessons learned from development.
Cellular plasticity within the pancreas--lessons learned from development.
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胰腺内的细胞可塑性 - 不从发育中学到的。
DOI：
10.1016/j.devcel.2010.02.005
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发表时间：
2010-03-16
影响因子：
11.8
通讯作者：
Hebrok, Matthias
中科院分区：
文献类型：
--
作者：
Puri, Sapna;Hebrok, Matthias
由于胰腺功能障碍导致的衰弱疾病，胰腺一直是密集研究的对象。在这篇综述中，我们总结了目前对小鼠胚胎前庭区域一小群细胞在胰腺形成过程中发生的关键组织相互作用和细胞内调节事件的理解。重要的是，对支配这个器官发育的原理的理解为我们提供了在再生医学的背景下操纵胚胎和分化的成人细胞的手段。成人胰腺内新出现的谱系调节区域特别令人感兴趣，该综述总结了最近的发现，例证了如何应用从发育中学到的经验教训来揭示完全分化的细胞改变命运的潜力。
The pancreas has been the subject of intense research due to the debilitating diseases that result from its dysfunction. In this review, we summarize current understanding of the critical tissue interactions and intracellular regulatory events that take place during formation of the pancreas from a small cluster of cells in the foregut domain of the mouse embryo. Importantly, an understanding of principles that govern the development of this organ has equipped us with the means to manipulate both embryonic and differentiated adult cells in the context of regenerative medicine. The emerging area of lineage modulation within the adult pancreas is of particular interest, and this review summarizes recent findings that exemplify how lessons learned from development are being applied to reveal the potential of fully differentiated cells to change fate.
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影响因子：
11.8
作者：
Chung, Won-Suk;Shin, Chong Hyun;Stainier, Didier Y. R.
通讯作者：
Stainier, Didier Y. R.
影响因子：
4.6
作者：
Esni, F;Ghosh, B;Leach, SD
通讯作者：
Leach, SD
影响因子：
64.8
作者：
Apelqvist, Å;Li, H;Edlund, H
通讯作者：
Edlund, H
影响因子：
8
作者：
Eberhard, D.;Tosh, D.;Slack, J. M. W.
通讯作者：
Slack, J. M. W.
影响因子：
64.8
作者：
Dor, Y;Brown, J;Melton, DA
通讯作者：
Melton, DA