Inflammatory large bowel disease in immunodeficient rats naturally and experimentally infected with Helicobacter bilis
Inflammatory large bowel disease in immunodeficient rats naturally and experimentally infected with Helicobacter bilis
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DOI：
10.1177/030098589803500305
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发表时间：
1998-05-01
影响因子：
2.4
通讯作者：
Ward, JM
中科院分区：
文献类型：
--
作者：
Haines, DC;Gorelick, PL;Ward, JM
在一个雄性裸胸大鼠（Cr:NIH-rnu）繁殖群体中偶然发现了增殖性和溃疡性斑疹伤寒、结肠炎和直肠炎。在大肠隐窝中，改良的斯坦纳银染色显示出螺旋生物体，通过培养、聚合酶链反应和测序鉴定为幽门螺杆菌。大肠疾病在无胆裂杆菌的雄性胸腺裸大鼠中复制，这些裸鼠腹腔注射受感染菌落的胆裂杆菌培养物。从实验感染大鼠的粪便和盲肠中分离出该菌。在免疫功能低下的大鼠中，胆门螺杆菌应被认为是一种潜在的病原体。免疫功能低下大鼠的感染可作为炎症性大肠病的动物模型。
Proliferative and ulcerative typhlitis, colitis, and proctitis were found incidentally in a breeding colony of male athymic nude (Cr:NIH-rnu) rats. Within the crypts of the large intestine, modified Steiner's silver stain revealed spiral organisms that were identified by culture, polymerase chain reaction, and sequencing to be Helicobacter bills. The large bowel disease was reproduced in H. bilis-free male athymic nude rats that were injected intraperitoneally with a culture of H. bilis from the affected colony. The organism was isolated from the feces and cecum of the experimentally infected rats. H. bilis should be considered a potential pathogen in immunocompromised rats. The infection in immunocompromised rats may serve as an animal model for inflammatory large bowel disease.