1,25-dihydroxycholecalciferol inhibits the progression of arthritis in murine models of human arthritis
1,25-dihydroxycholecalciferol inhibits the progression of arthritis in murine models of human arthritis
复制标题
DOI：
10.1093/jn/128.1.68
复制
发表时间：
1998-01-01
影响因子：
4.2
通讯作者：
DeLuca, HF
中科院分区：
文献类型：
--
作者：
Cantorna, MT;Hayes, CE;DeLuca, HF
1，25-二羟基胆钙化醇[1，25-（OH）（2）D-3]已被证明可抑制实验性自身免疫性脑脊髓炎（EAE）的进展。在这里，我们测试的可能性，1，25-二羟基胆钙化醇可能是治疗另一种自身免疫性疾病，关节炎。测试了两种不同的关节炎动物模型，即鼠莱姆关节炎和胶原诱导的关节炎。用伯氏疏螺旋体（人类莱姆关节炎的病原体）感染小鼠产生急性关节炎病变，包括足垫和踝关节肿胀。向感染B的小鼠补充充足的饲料中的1，25-二羟基胆钙化醇。burgdorferi最小化或预防了这些症状。用II型胶原免疫的小鼠也发生关节炎。这种疾病的症状也可以通过饮食补充I，25-二羟基胆钙化醇来预防。与未经治疗的对照组相比，给予具有胶原诱导关节炎早期症状的小鼠1，25-二羟基胆钙化醇可防止进展为严重关节炎。这些结果表明，1，25-二羟基胆钙化醇和/或其类似物可能是一种有价值的治疗方法，这种疾病。
1,25-Dihydroxycholecalciferol [1,25-(OH)(2)D-3], has been shown to inhibit the progression of experimental autoimmune encephalomyelitis (EAE). Here we tested the possibility that 1,25-dihydroxycholecalciferol might be therapeutic for another autoimmune disease, arthritis. Two different animal models of arthritis were tested, namely, murine Lyme arthritis and collagen-induced arthritis. Infection of mice with Borrelia burgdorferi (the causative agent of human Lyme arthritis) produced acute arthritic lesions including footpad and ankle swelling. Supplementation with 1,25-dihydroxycholecalciferol of an adequate diet fed to mice infected with B. burgdorferi minimized or prevented these symptoms. Mice immunized with type II collagen also developed arthritis. The symptoms of this disease were also prevented by dietary supplementation with I,25-dihydroxycholecalciferol. 1,25-Dihydroxycholecalciferol given to mice with early symptoms of collagen-induced arthritis prevented the progression to severe arthritis compared with untreated controls. These results suggest that 1,25-dihydroxycholecalciferol and/or its analogs may be a valuable treatment approach to this disease.