Comprehensive Histologic Scoring to Maximize the Predictability of Pathology-generated Equation of Breast Cancer Oncotype DX Recurrence Score.
Comprehensive Histologic Scoring to Maximize the Predictability of Pathology-generated Equation of Breast Cancer Oncotype DX Recurrence Score.
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DOI：
10.1097/pai.0000000000000248
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Opyrchal M
中科院分区：
文献类型：
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作者：
Khoury T;Huang X;Chen X;Wang D;Liu S;Opyrchal M
已引入病理学生成的方程来预测乳腺癌的肿瘤型DX复发评分(ORS)。研究的目的是对这些方程进行改进。我们回顾了416例(测试组)连续的乳腺癌患者的DX癌基因。使用从测试集生成的公式对验证集(n=91)进行前瞻性评分。组织病理学分级如下：Nottingham分级(指定为当前的Nottingham分级)、坏死和肿瘤浸润性淋巴细胞(TIL)程度。以下数据摘自病理报告：Nottingham分级(指定为已报道的Nottingham分级)、肿瘤大小、ER/PR Allred评分、HER2状态和ORS。计算了方程，一个包括报道的Nottingham分级，一个包括当前的Nottingham分级，一个包括当前的Nottingham分级和其他重要的组织病理学变量。在包括Nottingham分级、ER、PR和HER2的方程中，与ORS的总体符合率为64.86%。剔除公式检测的中间类后，符合率为95.28%。当计入当前诺丁汉评分时，符合率分别为69.61%和98.62%。将TIL的坏死率和TIL程度加到前一个方程中，这两个比率分别为70.1%和98.63%。与以前发表的结果相比，我们的方程与ORS具有更好的相关性。
Pathology generated equations have been introduced to predict Oncotype DX recurrence score (ORS) in breast cancer. The purpose of the study is to improve these equations. Slides from 416 (test set) consecutive breast cancers with available Oncotype DX were reviewed. A validation set (n=91) was prospectively scored using the generated formulas from the test set. The following histopathologic features were graded: Nottingham grade (designated as current Nottingham grade), necrosis, and degree of tumor infiltrating lymphocytes (TIL). The following data were extracted from the pathology report: Nottingham grade (designated as reported Nottingham grade), tumor size, ER/PR Allred scores, HER2 status, and ORS. Equations were calculated, one included the reported Nottingham grade, one included the current Nottingham grade, and one included the current Nottingham grade with the other significant histopathologic variables. In the equation that included the reported Nottingham grade, ER, PR and HER2, the overall concordance with the ORS was 64.86%. After excluding the intermediate category detected by the formula, the concordance rate was 95.28%. When the current Nottingham grade was included, the concordance rate became 69.61% and 98.62%, respectively. When necrosis and the degree of TIL were added to the previous equation, these rates became 70.1% and 98.63%, respectively. Our equation has better correlation to ORS than previously published results.