FPIA: A database for gene fusion profiling and interactive analyses
FPIA: A database for gene fusion profiling and interactive analyses
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FPIA：基因融合分析和交互分析的数据库
DOI：
10.1002/ijc.33921
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发表时间：
2022-02-05
影响因子：
6.4
通讯作者：
Xiong, Yuanyan
中科院分区：
文献类型：
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作者：
Huang, Lu;Zhu, Huimin;Xiong, Yuanyan
基因融合作为肿瘤的标志之一，在肿瘤的发生发展中起着重要的作用，已被确定为生物标志物和治疗靶点。尽管近年来基因融合数据库得到了发展，但缺乏具有交互分析功能的工具。在这里，我们介绍了融合简档交互分析(FPIA)，这是一个对融合基因进行交互和定制分析的网络服务器。有了这个平台，研究人员可以轻松地探索融合相关的生物学和分子差异，包括基因表达、肿瘤纯度和倍体、突变、拷贝数变化、蛋白质表达、免疫细胞渗透、茎干、端粒长度、微卫星不稳定性、生存率和基于癌症基因组图谱(TCGA)数据的33种癌症的新肽。目前，它包含来自6,910名患者的31个 633融合事件。FPIA以其多组学分析能力、集成分析功能、定制分析选择和用户友好的设计来补充现有的基因融合注释数据库。FPIA的全面数据分析将极大地促进数据挖掘、假设生成和治疗靶点的发现。如需查询，请登录：http://bioinfo-sysu.com/fpia.。
As one of the hallmarks of cancer, gene fusions play an important role in tumorigenesis, and have been established as biomarkers and therapeutic targets. Although recent years have witnessed the development of gene fusion databases, a tool with interactive analytic functions remains lacking. Here, we introduce fusion profiling interactive analysis (FPIA), a web server to perform interactive and customizable analysis on fusion genes. With this platform, researchers can easily explore fusion‐associated biological and molecular differences including gene expression, tumor purity and ploidy, mutation, copy number variations, protein expression, immune cell infiltration, stemness, telomere length, microsatellite instability, survival and novel peptides based on 33 cancer types from The Cancer Genome Atlas (TCGA) data. Currently, it contains 31 633 fusion events from 6910 patients. FPIA complements the existing gene fusion annotation databases with its multiomics analytic capacity, integrated analysis features, customized analysis selection and user‐friendly design. The comprehensive data analyses by FPIA will greatly facilitate data mining, hypothesis generation and therapeutic target discovery. FPIA is available at http://bioinfo-sysu.com/fpia.