In silico biophysics and hemorheology of blood hyperviscosity syndrome.
In silico biophysics and hemorheology of blood hyperviscosity syndrome.
复制标题
血液高粘度综合征的计算机生物物理学和血液流变学。
DOI：
10.1016/j.bpj.2021.05.013
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发表时间：
2021
影响因子：
3.4
通讯作者：
Jamali,Safa
中科院分区：
文献类型：
--
作者：
Javadi,Elahe;Deng,Yixiang;Karniadakis,GeorgeEm;Jamali,Safa
高粘滞综合征（HVS）的特征在于血液粘度增加至正常血液粘度的七倍，导致脉管系统中的循环紊乱。HVS通常与大血浆蛋白的增加和红细胞性质的异常相关，如细胞相互作用、细胞僵硬和血细胞比容增加。在这里，我们进行了系统的研究，每个生物物理因素对血液粘度的影响，采用耗散粒子动力学方法。我们的计算机平台能够单独操作每个参数，提供了一个独特的方案来量化和准确地研究每个因素在增加血液粘度中的作用。为了独立地研究这四个因素的影响，每个因素的升高超过健康血液的值，而其他因素保持恒定，并对不同的血细胞比容和流速进行粘度测量。虽然所有四个因素被发现增加整体血液粘度，这些增加是高度依赖于红细胞压积和施加的流速。细胞聚集和细胞浓度对血液粘度的影响主要是在低剪切速率下观察到的，相反，在高剪切速率下细胞刚性和血浆粘度的作用更大。此外，与血浆相关因子在较低血细胞比容时的相对作用相比，细胞相关因子在高血细胞比容时增加全血粘度。我们的研究结果，映射到流速和血细胞比容沿着循环系统，提供了一个相关性的基础机制HVS的发现在不同的血管。
Hyperviscosity syndrome (HVS) is characterized by an increase of the blood viscosity by up to seven times the normal blood viscosity, resulting in disturbances to the circulation in the vasculature system. HVS is commonly associated with an increase of large plasma proteins and abnormalities in the properties of red blood cells, such as cell interactions, cell stiffness, and increased hematocrit. Here, we perform a systematic study of the effect of each biophysical factor on the viscosity of blood by employing the dissipative particle dynamic method. Our in silico platform enables manipulation of each parameter in isolation, providing a unique scheme to quantify and accurately investigate the role of each factor in increasing the blood viscosity. To study the effect of these four factors independently, each factor was elevated more than its values for a healthy blood while the other factors remained constant, and viscosity measurement was performed for different hematocrits and flow rates. Although all four factors were found to increase the overall blood viscosity, these increases were highly dependent on the hematocrit and the flow rates imposed. The effect of cell aggregation and cell concentration on blood viscosity were predominantly observed at low shear rates, in contrast to the more magnified role of cell rigidity and plasma viscosity at high shear rates. Additionally, cell-related factors increase the whole blood viscosity at high hematocrits compared with the relative role of plasma-related factors at lower hematocrits. Our results, mapped onto the flow rates and hematocrits along the circulatory system, provide a correlation to underpinning mechanisms for HVS findings in different blood vessels.