Changes in the nervous control of the rat urinary bladder induced by outflow obstruction
Changes in the nervous control of the rat urinary bladder induced by outflow obstruction
复制标题
流出道梗阻引起大鼠膀胱神经控制的变化
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
B. Uvelius
中科院分区：
文献类型：
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作者：
A. Mattiasson;J. Ekstrom;B. Larsson;B. Uvelius
本实验观察了膀胱流出道梗阻对大鼠逼尿肌周围神经控制功能的影响。梗阻通过部分尿道结扎进行。梗阻6周后观察外源性药物和电场刺激对梗阻的影响。还测定了去甲肾上腺素和胆碱乙酰转移酶的含量以及α肾上腺素受体的密度。与正常对照组相比，梗阻膀胱对α肾上腺素受体刺激的收缩反应显著降低。阻塞膀胱中α肾上腺素受体的密度也降低。氨甲酰胆碱的浓度-反应关系保持不变，电诱导的神经介导的收缩反应的胆碱能和非胆碱能成分之间的关系也没有任何变化。阻塞膀胱的频率响应曲线发生了13 Hz的50%的最大响应，而对照组的频率响应曲线为4 Hz。梗阻6周后，去甲肾上腺素和胆碱乙酰转移酶的总量均增加，但由于膀胱壁明显肥大，其浓度仅为对照膀胱中浓度的约30%，梗阻1周和3周后也是如此。
The influence of bladder outflow obstruction on the peripheral nervous control of the detrusor was investigated in female rats. The obstruction was performed by means of partial urethral ligation. The influence of exogenously applied drugs and electrical field stimulation was investigated after obstruction for 6 weeks. The content of noradrenaline and choline acetyltransferase was also determined as well as the density of alpha‐adrenoceptors. A significant decrease of the contractile response to alpha‐adrenoceptor stimulation was found in the obstructed bladders when compared to normal controls. Also the density of alpha‐adrenoceptors decreased in the obstructed bladders. The concentrationresponse relationship to carbachol remained unchanged, and neither were any changes seen in the relation between the cholinergic and noncholinergic components of the electrically induced, nerve‐mediated contractile response. A rightward shift of the frequencyresponse curve for the obstructed bladders was found with 50% of the maximum response occurring at 13 Hz compared to 4 Hz in the control preparations. The total amount of both noradrenaline and choline acetyltransferase had increased after 6 weeks of obstruction, but owing to the pronounced degree of hypertrophy of the bladder wall the concentrations were only approximately 30% of those in the control bladders, which also was the case after 1 and 3 weeks of obstruction.
DOI：
10.1016/s0022-5347(17)49045-8
发表时间：
1985
期刊：
The Journal of urology
影响因子：
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作者：
Malkowicz,SB;Atta,MA;Elbadawi,A;Wein,AJ;Levin,RM
通讯作者：
Levin,RM