Regional cerebral blood flow in cocaine- versus methamphetamine-dependent patients with a history of alcoholism
Regional cerebral blood flow in cocaine- versus methamphetamine-dependent patients with a history of alcoholism
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DOI：
10.1017/s1461145701002334
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发表时间：
2001-06-01
影响因子：
4.8
通讯作者：
Grant, I
中科院分区：
文献类型：
--
作者：
Alhassoon, OM;Dupont, RM;Grant, I
虽然可卡因或甲基苯丙胺的滥用通常发生在大量饮酒的情况下，但关于这种物质使用合并症对脑灌注的影响的信息很少。我们利用SPECT探讨了这两种药物与酒精联合使用对脑功能影响的异同。对7名戒断性可卡因依赖酗酒者（CDA，平均年龄39.2岁，sd = 9.2岁）、7名戒断性甲基苯丙胺依赖酗酒者（MDA，平均年龄36.8岁，sd = 5.0岁）和7名非酒精/非兴奋剂滥用对照者（NAC，平均年龄37.3岁，sd = 9.6岁）进行了全球和区域脑血流量（CBF）检测。MDA的总体CBF显著低于CDA， CDA在朗姆酒中显著低于NAG。此外，与NAG相比，CDA在上后额区有异常灌注；而MDA没有显示出特定的区域赤字。因此，可卡因似乎改变了酗酒者的全球和区域脑血流循环之间的关系，而甲基苯丙胺则没有。
Although abuse of cocaine or methamphetamine usually takes place in the context of heavy drinking, there is little information on the effects of such substance use comorbidity on brain perfusion. We explored similarities and differences in the effects of these two drugs in combination with alcohol on brain function using SPECT. Global and regional cerebral blood flow (CBF) were examined in 7 abstinent cocaine-dependent alcoholics (CDA; mean age = 39.2 yr, S.D. = 9.2 yr), 7 abstinent methamphetamine-dependent alcoholics (MDA; mean age = 36.8 yr, S.D. = 5.0 yr), and 7 non-alcoholic/non-stimulant abusing controls (NAC; mean age = 37.3 yr, S.D. = 9.6 yr). MDA had significantly lower global CBF than CDA who, in rum, were significantly lower than NAG. In addition, CDA had abnormal perfusion in the superior posterior frontal region compared to NAG; while MDA did not display specific regional deficits. Therefore, it appears that cocaine alters the relationship between global and regional CBF in alcoholics, while methamphetamine does not.