Histamine Neuroimaging in Stress-Related Disorders.
Histamine Neuroimaging in Stress-Related Disorders.
复制标题
DOI：
10.1007/7854_2021_262
复制
发表时间：
2022-01-01
影响因子：
--
通讯作者：
Yanai, Kazuhiko
中科院分区：
文献类型：
--
作者：
Fukudo, Shin;Kano, Michiko;Yanai, Kazuhiko
尽管组胺在应激相关疾病的动物模型中发挥了主要作用，但人类神经成像数据很少。1992年柳井一彦教授利用H1受体的有效配体11C-多塞平和正电子发射断层扫描(PET)首次对人脑中的组胺H1受体进行了成像。随后的研究发现，在患有抑郁症的患者中，前额叶和前扣带回皮质的H1受体减少。大脑中H1受体结合的性别差异也被发现，女性比男性表现出更丰富的H1受体结合。此外，女性神经性厌食症患者杏仁核和豆状核的H1受体结合率较高。这些研究还发现，抑郁评分与H1受体结合呈负相关。组胺被认为在肠易激综合征(IBS)的病理生理学中起主要作用，IBS是一种典型的脑-肠道相互作用的疾病。按照这些思路，催眠暗示对直肠电刺激的反应会显著改变内脏感觉脑诱发电位的波形，这些变化可被给予H1拮抗剂改变。在IBS患者和健康对照组中，H1拮抗剂引起的内脏感觉脑诱发电位改变的方向不同。因此，组胺可能在应激相关疾病中起着重要作用。有必要对人类进行进一步的组胺脑成像研究。
Although histamine plays a major role in animal models of stress-related disorders, human neuroimaging data are sparse. Histamine H1 receptors in the human brain were first imaged by Professor Kazuhiko Yanai in 1992 by using 11C-doxepin, a potent ligand of H1 receptors, and positron emission tomography (PET). Subsequent work revealed that H1 receptors are reduced in the prefrontal and anterior cingulate cortices in patients with major depressive disorders. A sex difference in H1 receptor binding in the brain has also been found, with women exhibiting more abundant H1 receptor binding than men. Moreover, female patients with anorexia nervosa show higher H1 receptor binding in the amygdala and lentiform nucleus. These studies also found an inverse correlation of depression scores with H1 receptor binding. Histamine is considered to play a major role in the pathophysiology of irritable bowel syndrome (IBS), a representative disorder of brain-gut interactions. Along these lines, hypnotic suggestion dramatically changes the waveforms of viscerosensory cerebral evoked potentials in response to electrical rectal stimulation and these changes are modified by the administration of H1 antagonist. The direction of the H1 antagonist-induced changes in the viscerosensory cerebral evoked potentials differs between IBS patients and healthy controls. Thus, histamine likely plays an important role in stress-related disorders. Further histamine brain imaging studies of humans are warranted.