Survivin: a promising biomarker for detection and prognosis of bladder cancer
Survivin: a promising biomarker for detection and prognosis of bladder cancer
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DOI：
10.1007/s00345-007-0219-y
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发表时间：
2008-02-01
影响因子：
3.4
通讯作者：
Shariat, Shahrokh F.
中科院分区：
文献类型：
--
作者：
Margulis, Vitaly;Lotan, Yair;Shariat, Shahrokh F.
Survivin是一个分子量为16.5 kDa的凋亡抑制蛋白家族成员，在许多恶性肿瘤中过表达，但在正常分化的成人组织中很少检测到。在功能上，Survivin抑制细胞凋亡，促进细胞增殖，并诱导/增强血管生成。在膀胱移行细胞癌中，Survivin已被证明是癌症诊断、预后和预测膀胱内或全身治疗反应的有希望的生物标志物。此外，在临床前膀胱肿瘤模型中，抑制Survivin表达和/或功能已显示阻碍肿瘤细胞增殖，并显著诱导自发或化疗诱导的细胞凋亡。这些初步发现现在应该在大型前瞻性试验中得到证实。此外，简化，定量和可重复的检测方法需要开发和验证的检测存活素及其不同的亚型。
Survivin is a 16.5 kDa member of the inhibitor of apoptosis protein family that is overexpressed in many malignancies but rarely detected in normal differentiated adult tissues. Functionally, Survivin inhibits apoptosis, promotes cell proliferation, and induces/enhances angiogenesis. In transitional cell carcinoma of the urinary bladder, Survivin has been shown to be a promising biomarker for cancer diagnosis, prognosis and prediction of response to intravesical or systemic therapies. Moreover, in pre-clinical bladder tumor models, inhibition of Survivin expression and/or function has been shown to impede tumor cell proliferation, and markedly induce spontaneous or chemotherapy induced apoptosis. These preliminary findings should now be confirmed in large prospective trials. Furthermore, simplified, quantitative and reproducible assays need to be developed and validated for the detection of Survivin and its different isoforms.