AKR1B10 is Associated with Smoking and Smoking-related Non-small-cell Lung Cancer
AKR1B10 is Associated with Smoking and Smoking-related Non-small-cell Lung Cancer
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DOI：
10.1177/147323001103900110
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发表时间：
2011-01-01
影响因子：
1.6
通讯作者：
Kim, H.
中科院分区：
文献类型：
--
作者：
Kang, M-W;Lee, E-S;Kim, H.
本前瞻性研究探讨了AKR 1B 10 mRNA表达与非小细胞肺癌（NSCLC）各种临床参数之间的关系，以验证其作为NSCLC标志物。从229名NSCLC患者中收集肿瘤组织样本。这些患者中的89名的邻近非恶性肺组织（距离肿瘤> 5cm）的组织样品和20名患有良性肺病的患者的样品用作对照。定量逆转录-聚合酶链反应显示，AKR 1B 10 mRNA在NSCLC肿瘤组织中的表达水平显著高于邻近的非恶性肺组织和良性肺组织。AKR 1B 10 mRNA过表达的统计学显著性因素为男性、吸烟、鳞状细胞癌和中、低分化细胞。得出的结论是，AKR 1B 10似乎有潜力作为非小细胞肺癌的预后标志物，值得进一步研究。
This prospective study explored the relationship between expression of AKR1B10 mRNA and various clinical parameters in non-small-cell lung cancer (NSCLC) in terms of its validation as a marker for NSCLC. Tumour tissue samples were collected from 229 patients with NSCLC. Tissue samples from adjacent nonmalignant lung tissue (> 5 cm from the tumour) of 89 of these patients and samples from 20 patients with benign lung disease were used as controls. Quantitative reverse transcription-polymerase chain reaction showed significantly higher levels of AKR1B10 mRNA expression in NSCLC tumour tissue than in adjacent non-malignant lung tissue and benign lung tissue. Statistically significant factors for AKR1B10 mRNA over-expression were found to be male gender, smoking, squamous cell carcinoma and moderate or poor cell differentiation. It is concluded that AKR1B10 seems to have potential as a prognostic marker for NSCLC and warrants further investigation.