Cognitive impairment among methadone maintenance patients
Cognitive impairment among methadone maintenance patients
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DOI：
10.1046/j.1360-0443.2000.9556874.x
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发表时间：
2000-05-01
期刊：
影响因子：
6
通讯作者：
Wickes, W
中科院分区：
文献类型：
--
作者：
Darke, S;Sims, J;Wickes, W
目标。比较美沙酮维持治疗患者（MMPs）和匹配的非海洛因使用对照受试者的认知表现，并确定认知表现较差的危险因素。设计匹配对照研究。设置.澳大利亚悉尼。参与者30名MMPs和30名非海洛因使用对照，年龄，性别和教育相匹配。调查结果。MMP组有显着高于对照组的酒精依赖，海洛因过量和头部受伤。两组的病前功能没有差异。MMP组在所有测量的神经心理学领域的表现均显着低于对照组：信息处理，注意力，短期视觉记忆，延迟视觉记忆，短期言语记忆，长期言语记忆和解决问题。酒精依赖的终生诊断和非致命性海洛因过量的数量是认知能力较差的独立重要预测因素。结论.除了精神病发病率高，MMPs也显示出认知缺陷相比，匹配的对照。酒精依赖史和反复过量暴露会增加认知障碍的可能性。目前的研究并不排除其他因素的可能性，这些因素没有被测量，可能会导致这种MMPs中的认知障碍。
Aims. To compare the cognitive performance of methadone maintenance patients (MMPs) and a matched sample of non-heroin-using control subjects, and to ascertain risk factors for poorer cognitive performance. Design. Matched control study. Setting. Sydney, Australia. Participants. Thirty MMPs and 30 non-heroin using controls, matched for age, gender and education. Findings. The MMP group had significantly higher rates than controls of alcohol dependence, heroin overdose and head injury. There was no difference between the groups on pre-morbid functioning. The MMP group performed significantly poorer than controls on all of the neuropsychological domains measured: information processing, attention, short-term visual memory, delayed visual memory, short-term verbal memory, long-term verbal memory and problem solving. A life-time diagnosis of alcohol dependence and the number of non-fatal heroin overdoses were independent significant predictors of poorer cognitive performance. Conclusions. In addition to high rates of psychiatric morbidity, MMPs also show cognitive deficits compared to matched controls. A history of alcohol dependence and repeated exposure to overdose increase the likelihood of cognitive impairment. The current study does not rule out the possibility of other factors, that were not measured, that may contribute to cognitive impairment among this MMPs.