Sodium chloride affects Helicobacter pylori growth and gene expression
Sodium chloride affects Helicobacter pylori growth and gene expression
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DOI：
10.1128/jb.01728-07
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发表时间：
2008-06-01
影响因子：
3.2
通讯作者：
Merrell, D. Scott
中科院分区：
文献类型：
--
作者：
Gancz, Hanan;Jones, Kathleen R.;Merrell, D. Scott
流行病学证据将高盐饮食和幽门螺杆菌感染与胃病风险增加联系起来。氯化钠含量升高导致这些表现的机制尚不清楚。在这里，我们描述的响应H。幽门螺杆菌的生长，细胞形态，存活和毒力因子的表达都改变了盐浓度的增加。
Epidemiological evidence links high-salt diets and Helicobacter pylori infection with increased risk of developing gastric maladies. The mechanism by which elevated sodium chloride content causes these manifestations is unclear. Here we characterize the response of H. pylori to temporal changes in sodium chloride concentration and show that growth, cell morphology, survival, and virulence factor expression are all altered by increased salt concentration.