Overexpression of AIB1 in nasopharyngeal carcinomas correlates closely with advanced tumor stage
Overexpression of AIB1 in nasopharyngeal carcinomas correlates closely with advanced tumor stage
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DOI：
10.1309/qmdtl82jkex6e7h2
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发表时间：
2008-05-01
影响因子：
3.5
通讯作者：
Zeng, Yi-Xin
中科院分区：
文献类型：
--
作者：
Liu, Meng-Zhong;Xie, Dan;Zeng, Yi-Xin
AM-1是乳腺癌的候选癌基因，在多种类型的人类癌症中普遍扩增和过度表达。本研究采用免疫组织化学和荧光原位杂交技术，对80例鼻咽癌组织和20例鼻咽非肿瘤性黏膜组织中AIB1基因的表达和扩增进行了研究。在这个鼻咽癌队列中，AIB1的过度表达和扩增分别在71例鼻咽癌中36例(51%)和46例鼻咽癌中3例(7%)被检测到。AIB1在T分期晚期(T3/T4,24135[69%])的表达高于早期(T1/T2,12136[33%]；P
AM 1, a candidate oncogene in breast cancer, is commonly amplified and overexpressed in several types of human cancers. In this study, expression and amplification of AIB1 in nasopharyngeal carcinoma (NPC) were studied by immunohistochemical analysis and fluorescence in situ hybridization using tissue microarrays, including 80 specimens of NPC and 20 specimens of nonneoplastic nasopharyngeal mucosa. In this NPC cohort, overexpression and amplification of AIB1 was detected in 36 (51 %) of 71 and 3 (7%) of 46 NPCs, respectively. Overexpression of AIB1 was observed more frequently in NPCs in late T stages (T3/T4, 24135 [69%]) than in earlier stages (T1/T2, 12136 [33%]; P