Glutamine and cancer
Glutamine and cancer
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DOI：
10.1093/jn/131.9.2539s
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发表时间：
2001-09-01
影响因子：
4.2
通讯作者：
Medina, MA
中科院分区：
文献类型：
--
作者：
Medina, MA
谷氨酰胺是人体中最丰富的游离氨基酸;它是正常和肿瘤细胞生长以及许多细胞类型培养所必需的。癌症被描述为氮陷阱。肿瘤的存在使宿主谷氨酰胺代谢发生巨大变化，从而使宿主氮代谢适应肿瘤对谷氨酰胺的需求。为了使用，谷氨酰胺必须被转运到肿瘤线粒体中。因此，概述谷氨酰胺在癌症中的作用不仅需要讨论宿主和肿瘤谷氨酰胺代谢，还需要讨论其循环和运输。由于谷氨酰胺缺乏对宿主有不利影响，因此还应研究谷氨酰胺补充剂在荷瘤状态下的作用。本文综述了谷氨酰胺和癌症的知识状况，包括潜在的治疗意义。
Glutamine is the most abundant free amino acid in the human body; it is essential for the growth of normal and neoplastic cells and for the culture of many cell types. Cancer has been described as a nitrogen trap, The presence of a tumor produces great changes in host glutamine metabolism in such a way that host nitrogen metabolism is accommodated to the tumor-enhanced requirements of glutamine. To be used, glutamine must be transported into tumor mitochondria. Thus, an overview of the role of glutamine in cancer requires not only a discussion of host and tumor glutamine metabolism, but also its circulation and transport. Because glutamine depletion has adverse effects for the host, the effect of glutamine supplementation in the tumor-bearing state should also be studied. This communication reviews the state of knowledge of glutamine and cancer, including potential therapeutic implications.