The tetrameric structure of a glutamate receptor channel
The tetrameric structure of a glutamate receptor channel
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DOI：
10.1126/science.280.5369.1596
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发表时间：
1998-06-05
期刊：
影响因子：
56.9
通讯作者：
Stevens, CF
中科院分区：
文献类型：
--
作者：
Rosenmund, C;Stern-Bach, Y;Stevens, CF
几种配体门控离子通道受体的亚基化学计量仍然是未知的。本文报道了一种计算谷氨酸受体亚基数目的方法。该方法在HEK细胞系中的成功应用证明了离子型谷氨酸受体与电压门控钾通道具有四聚体结构。这些通道的平均电导取决于有多少亚基被激动剂占据。
The subunit stoichiometry of several ligand-gated ion channel receptors is still unknown. A counting method was developed to determine the number of subunits in one family of brain glutamate receptors, Successful application of this method in an HEK cell line provides evidence that ionotropic glutamate receptors share a tetrameric structure with the voltage-gated potassium channels. The average conductance of these channels depends on how many subunits are occupied by an agonist.