SUPRACHIASMATIC NUCLEUS LESION INCREASES CORTICOSTERONE SECRETION
SUPRACHIASMATIC NUCLEUS LESION INCREASES CORTICOSTERONE SECRETION
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DOI：
10.1152/ajpregu.1993.264.6.r1186
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发表时间：
1993-06-01
影响因子：
--
通讯作者：
SHINN, S
中科院分区：
文献类型：
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作者：
BUIJS, RM;KALSBEEK, A;SHINN, S
皮质类固醇分泌的昼夜节律由视交叉上核（SCN）控制。在大鼠中，血浆皮质类固醇水平在黑暗阶段的活动期开始之前上升。我们之前的结果表明，加压素作为 SCN 的神经递质，抑制下丘脑室旁/背内侧核区域的皮质类固醇分泌。我们假设白天视交叉上核可能充当皮质类固醇分泌的抑制系统。为了研究这种可能性，完整的和 SCN 损伤的动物在早上和晚上受到轻微的压力，并监测它们的血浆皮质类固醇水平。结果表明，与未受损的对照动物相比，SCN 损伤的动物早晨皮质类固醇水平较高，并且在应激后的早晨和晚上均具有较高的皮质类固醇水平。因此，我们得出结论，这些结果表明 SCN 对皮质类固醇分泌的抑制作用。讨论了 SCN 对促肾上腺皮质激素分泌的刺激作用与报道的明显差异。
The diurnal rhythm of corticosteroid secretion is controlled by the suprachiasmatic nucleus (SCN). In rats, plasma corticosteroid levels rise just before the onset of the activity period during the dark phase. Our previous results indicated that vasopressin as a neurotransmitter from the SCN inhibited corticosteroid secretion in the area of the paraventricular/dorsomedial nucleus of the hypothalamus. We hypothesized that during the day the SCN may serve as an inhibitory system for corticosteroid secretion. To investigate this possibility, intact and SCN-lesioned animals were exposed to mild stress in the morning and evening and their plasma corticosteroid levels were monitored. The results indicate that SCN-lesioned animals have higher morning corticosteroid levels and respond both in the morning and evening with higher corticosteroid levels after stress than do intact control animals. We conclude, therefore, that these results indicate an inhibitory role of the SCN on corticosteroid secretion. The apparent discrepancy with the reported stimulatory role of the SCN on adrenocorticotropic hormone secretion is discussed.