Sources of movement-related cortical potentials derived from foot, finger, and mouth movements.
Sources of movement-related cortical potentials derived from foot, finger, and mouth movements.
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DOI：
10.1097/00004691-199907000-00009
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发表时间：
1999-07
期刊：
影响因子：
--
通讯作者：
G. W. Milliken;D. Stokic;I. M. Tarkka
中科院分区：
文献类型：
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作者：
G. W. Milliken;D. Stokic;I. M. Tarkka
运动相关皮层电位（MRCP）记录运动执行之前和期间的脑电活动。为了描述MRCP的组成部分，反映了各种运动的共同来源，并且是运动特异性的，研究了简单的自主步速的脚、手指和嘴的运动。在8名健康志愿者的头皮上放置30个电极，记录MRCP。使用脑电源分析软件分析数据，并开发多个等效偶极子模型，以分离与自主运动执行相关的脑活动的空间和时间方面。独立的模型分别为总平均数据和每个运动类型的个体受试者的数据开发。使用5-偶极子模型解释来自足部运动的MRCP，使用8-偶极子模型解释手指运动，使用7-偶极子模型解释嘴巴运动，分别产生3%、2%和6%的总平均残差方差。基于个体模型，偶极子位置的受试者间变异性小于10 mm（+/- SD）。将平均偶极子坐标叠加到立体定位图谱上，证明感觉运动皮层区、辅助运动区以及小脑和丘脑在所有三种运动中都是活跃的。偶极子在对侧感觉运动区的位置清楚地暗示了众所周知的脚、手指和嘴运动的内侧到外侧躯体定位组织。在偶极子源电位的时刻的演变证明了在不同的大脑区域传播的活动的时间分离。作者的模型支持运动执行时初级运动皮层和辅助运动区同时激活的观点。在这项研究中开发的多个等效偶极子模型暗示了先前通过正电子发射断层扫描或功能性磁共振成像检测到的源自相应脑区的活动。然而，MRCP提供了额外的信息，关于执行自愿运动的大脑活动的时间演变。因此，同时使用MRCP和其他成像技术可以提供其他成像技术本身不容易获得的补充信息。
Movement-related cortical potentials (MRCPs) register brain electrical activity before and during movement execution. In an attempt to delineate the components of MRCPs that reflect common sources to various movements and that are movement-specific, simple self-paced voluntary foot, finger, and mouth movements were studied. MRCPs were recorded in eight healthy volunteers with 30 electrodes placed on the scalp. Data were analyzed using Brain Electric Source Analysis software, and multiple equivalent dipole models were developed to separate spatial and temporal aspects of brain activity related to the execution of voluntary movements. Independent models were separately developed for the grand average data and for the individual subjects' data for each movement type. MRCPs derived from foot movements were accounted for using a 5-dipole model, finger movements using an 8-dipole model, and mouth movements with a 7-dipole model, yielding the grand average residual variances of 3%, 2%, and 6%, respectively. Based on individual models, intersubject variability of dipole locations was less than 10 mm (+/- SD). Overlaying the mean dipole coordinates onto the stereotaxic atlas provided proof that the sensorimotor cortical areas, supplementary motor area, and also cerebellum and thalamus were active in all three movements. Locations of the dipoles in the contralateral sensorimotor area clearly implied well-known medial to lateral somatotopic organization of foot, finger, and mouth movements. Temporal separation of the activity spread over different brain areas was demonstrated by evolution in the moments of dipole source potentials. The authors' models support the view of simultaneous activation of the primary motor cortex and supplementary motor area at the time of movement execution. Multiple equivalent dipole models developed in this study implied the activity originating in corresponding brain areas as previously detected by positron emission tomography or functional magnetic resonance imaging. However, MRCPs provided additional information regarding the temporal evolution of the brain activity related to the execution of voluntary movements. Thus, the concurrent use of MRCPs and other imaging techniques may provide complementary information not easily obtained by the other imaging techniques themselves.