Schistosomiasis and the risk of bladder cancer in Alexandria, Egypt.
Schistosomiasis and the risk of bladder cancer in Alexandria, Egypt.
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DOI：
10.1038/bjc.1998.197
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发表时间：
1998-04
影响因子：
8.8
通讯作者：
La Vecchia, C
中科院分区：
文献类型：
--
作者：
Bedwani, R;Renganathan, E;El Kwhsky, F;Braga, C;Abu Seif, H H;Abul Azm, T;Zaki, A;Franceschi, S;Boffetta, P;La Vecchia, C
使用1994年1月至1996年7月在埃及亚历山大进行的病例对照研究的数据，对血吸虫病史和膀胱癌风险之间的关系进行了研究。病例为190例组织学证实的浸润性膀胱癌患者，对照组为187例因急性、非肿瘤性、非尿路疾病住院的患者。86例（45%）和69例对照（37%）报告了泌尿系血吸虫病史。在排除年龄、性别、教育、吸烟、其他泌尿系感染和高危职业后，膀胱癌相应的多变量比值比（OR）为1.72（95%置信区间（CI）1.0-2.9）。肠型血吸虫病的OR值为0.22（95% CI 0.1-0.4），其他类型血吸虫病的OR值为0.32（95% CI 0.1-1.9）。尿血吸虫病的OR在首次诊断时较年轻的受试者（<15岁的OR为3.3）和首次诊断后较长时间的受试者（≥ 35岁的OR为3.0）中较高。与无尿路血吸虫病史的从不吸烟者相比，有尿路血吸虫病史的男性吸烟者的OR为15.8，与从未感染过尿路血吸虫病且曾从事高危职业的男性相比，从未感染过尿路血吸虫病且无高危职业史的男性的OR为3.2。这项研究证实，尿路血吸虫病的临床病史是显着的，但适度，与膀胱癌的风险增加，解释了约16%的膀胱癌病例在这个埃及人口。
The relationship between history of schistosomiasis and bladder cancer risk was investigated using data from a case-control study conducted between January 1994 and July 1996 in Alexandria, Egypt. Cases were 190 subjects with incident, histologically confirmed invasive cancer of the bladder, and controls were 187 subjects admitted to hospital for acute, non-neoplastic, non-urinary tract conditions. Eighty-six cases (45%) vs 69 controls (37%) reported a history of urinary schistosomiasis. The corresponding multivariate odds ratio (OR) of bladder cancer -- after allowance for age, sex, education, smoking, other urinary infections and high-risk occupations -- was 1.72 (95% confidence interval (CI) 1.0-2.9). The ORs were 0.22 (95% CI 0.1-0.4) for intestinal schistosomiasis and 0.32 (95% CI 0.1-1.9) for schistosomiasis of other types. The OR for urinary schistosomiasis was higher in subjects who were younger at first diagnosis (OR of 3.3 for <15 years) and in those with a long time since first diagnosis (OR of 3.0 for > or = 35 years). The ORs were 15.8 for male ever-smokers with a history of urinary schistosomiasis, compared with never-smokers without such a history, and 3.2 for men ever-infected with urinary Schistosoma haematobium and ever-employed in high-risk occupations, compared with those never-infected and with no high-risk occupational history. This study confirms that clinical history of urinary schistosomiasis is significantly, but modestly, associated with increased bladder cancer risk, explaining some 16% of bladder cancer cases in this Egyptian population.