THE CHEMISTRY OF SELF-SPLICING RNA AND RNA ENZYMES
THE CHEMISTRY OF SELF-SPLICING RNA AND RNA ENZYMES
复制标题
DOI：
10.1126/science.2438771
复制
发表时间：
1987-06-19
期刊：
影响因子：
56.9
通讯作者：
CECH, TR
中科院分区：
文献类型：
--
作者：
CECH, TR
蛋白质并不是细胞反应的唯一催化剂;有越来越多的RNA分子催化RNA切割和连接反应。重点讨论了四膜虫核糖体RNA前体的自剪接及其插入序列RNA的酶活性。在适当的情况下，将RNA的催化作用与蛋白酶的催化作用进行比较。
Proteins are not the only catalysts of cellular reactions; there is a growing list of RNA molecules that catalyze RNA cleavage and joining reactions. The chemical mechanisms of RNA-catalyzed reactions are discussed with emphasis on the self-splicing ribosomal RNA precursor ofTetrahymenaand the enzymatic activities of its intervening sequence RNA. Wherever appropriate, catalysis by RNA is compared to catalysis by protein enzymes.