ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort
ABO blood type, factor VIII, and incident cognitive impairment in the REGARDS cohort
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DOI：
10.1212/wnl.0000000000000844
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发表时间：
2014-09-30
期刊：
影响因子：
9.9
通讯作者：
Cushman, Mary
中科院分区：
文献类型：
--
作者：
Alexander, Kristine S.;Zakai, Neil A.;Cushman, Mary
目的：在一项针对美国黑人和白人成年人的大型前瞻性队列研究中，采用巢式病例对照设计，评估 ABO 群体、因子 VIII (FVIII) 和偶发性认知障碍之间的关系。方法：通过平均随访 3.4 年的认知领域测试来定义偶发性认知障碍。通过对 495 名认知障碍患者和 587 名对照者的巢式病例对照样本进行基因分型来测量 ABO 血型。结果：调整年龄、种族、地区和性别后，AB 型血型和 FVIII 较高的人患认知障碍的风险增加（比值比分别为 1.82，95% 置信区间 [CI] 1.15-2.90；1.24，95% CI） FVIII 增加 40 IU/dL 时为 1.10-1.38)。与 O 型血者 (104 IU/dL; 95% CI 101-107) 相比，AB 型血者的平均 FVIII 较高 (142 IU/dL; 95% CI 119-165)，并且 FVIII 介导了 AB 型血型与认知障碍事件之间 18% 的关联（95% CI 介导为 230% 至 68%）。结论：AB 型血和较高的 FVIII 与血型增加相关这项前瞻性研究中认知障碍的发生率。 AB 血型与认知障碍的相关性并不受 FVIII 水平的显着介导。
Objective: To assess the relationships among ABO group, factor VIII (FVIII), and incident cognitive impairment in a large, prospective cohort study of black and white adults in the United States using a nested case-control design.Methods: Incident cognitive impairment was defined using cognitive domain tests over a mean follow-up of 3.4 years. ABO blood group was measured by genotyping in a nested case-control sample of 495 cases with cognitive impairment and 587 controls.Results: Those with blood group AB and those with higher FVIII had an increased risk of cognitive impairment, adjusting for age, race, region, and sex (respective odds ratios 1.82, 95% confidence interval [CI] 1.15-2.90; and 1.24, 95% CI 1.10-1.38 for 40 IU/dL higher FVIII). Mean FVIII was higher in those with blood type AB (142 IU/dL; 95% CI 119-165) compared with O (104 IU/dL; 95% CI 101-107), and FVIII mediated 18% of the association between AB group and incident cognitive impairment (95% CI for mediation 230% to 68%).Conclusions: Blood group AB and higher FVIII were associated with increased incidence of cognitive impairment in this prospective study. The association of blood group AB with incident cognitive impairment was not significantly mediated by FVIII levels.