Role of the Hepatitis B virus proteins in pro- and anti-apoptotic processes
Role of the Hepatitis B virus proteins in pro- and anti-apoptotic processes
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DOI：
10.2741/3602
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发表时间：
2010-01-01
影响因子：
3.1
通讯作者：
Rossignol, Jean-Michel
中科院分区：
文献类型：
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作者：
Assrir, Nadine;Soussan, Patrick;Rossignol, Jean-Michel
B型肝炎病毒（HepatitisBvirus，HBV）可引起慢性肝炎、肝细胞癌等严重的肝脏疾病。事实上，细胞凋亡在这些疾病的发展中起着重要的作用。由于细胞凋亡通过各种外源性或内源性途径进行，伴随半胱天冬酶的激活和线粒体的可能参与，HBV蛋白可以干扰各种细胞凋亡过程。到目前为止，有四种HBV蛋白被报道具有这种作用：大包膜蛋白，中包膜蛋白的截短形式，HBx蛋白和HBSP，由剪接的mRNA产生的蛋白。此外，我们最近的研究结果表明，前C蛋白可能间接在细胞凋亡中发挥作用。本文综述了HBV蛋白作为促凋亡因子或抗凋亡因子的可能作用及其与HBV生命周期的关系。
The Hepatitis B virus (HBV) can induces severe liver diseases as chronic hepatitis and hepatocellular carcinoma. Actually, apoptosis can play an important role in the progress of these diseases. As apoptosis goes through various extrinsic or intrinsic pathways, with activation of caspases and the possible involvement of mitochondria, HBV proteins can interfere with the various apoptosis processes. So far, four HBV proteins were reported to have such effect: the Large envelope protein, a truncated form of the Middle envelope protein, the HBx protein and HBSP, a protein generated from a spliced mRNA. In addition, our recent results suggest that indirectly the precore protein could have a function in apoptosis. This review focuses on the putative roles of HBV proteins as pro- or anti-apoptotic factors and the relationship which could exist with the HBV life cycle.