The Detection of the Negative Effects of Interictal Epileptiform Discharges on Cognition An Event-Related Potential Study
The Detection of the Negative Effects of Interictal Epileptiform Discharges on Cognition An Event-Related Potential Study
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发作间期癫痫样放电对认知的负面影响的检测事件相关电位研究
DOI：
10.1097/nmd.0000000000000945
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发表时间：
2019
影响因子：
1.9
通讯作者：
Lv Yudan
中科院分区：
文献类型：
--
作者：
Sun Lihua;Zheng Xiangyu;Liu Chang;Shi Mingchao;Lv Yudan
神经心理学测试的证据表明，发作间期癫痫样放电（IEDs）可能对认知能力有显着影响。有时，神经心理学测试可能对轻度认知变化的检测不敏感。我们应用P300和失匹配负波（MMN）检测少量IED引起的轻度认知改变。将67例成人癫痫患者和参与者根据不同的IEDs指数分为6组。IED指数> 7.5%者P300和MMN潜伏期较IED指数< 7.5%者长，波幅较IED指数< 7.5%者低，提示轻度认知功能损害。神经心理学测验发现IED指数大于10%对认知功能有负性影响，而IED指数大于7.5%对认知功能有轻度负性影响，P300和MMN则未发现。因此，P300和MMN可能比神经心理学测验更敏感地检测IED引起的轻度认知功能损害。
Evidence from a neuropsychological test revealed that interictal epileptiform discharges (IEDs) may have significant impact on cognitive performance. Sometimes, neuropsychological tests may not be sensitive to detection of mild cognitive changes. We applied P300 and mismatch negativity (MMN) to detect mild cognitive changes caused by small amount of IEDs. Sixty-seven adult epilepsy patients and participants were divided into six groups according to different IEDs index. The patients with IED index greater than 7.5% showed longer latency and lower amplitude in the test of P300 and MMN than patients with IED index less than 7.5%, which indicated mild impaired cognitive function. The negative effect of IED index greater than 10% on cognitive has been found by neuropsychological test, whereas the mild negative effect of IED index greater than 7.5% has only been found by P300 and MMN. So, P300 and MMN may be more sensitive than neuropsychological tests to detect mild cognitive impairment caused by IEDs.