Plasma metabolomic profiling in subclinical atherosclerosis: the Diabetes Heart Study.
Plasma metabolomic profiling in subclinical atherosclerosis: the Diabetes Heart Study.
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DOI：
10.1186/s12933-021-01419-y
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发表时间：
2021-12-07
影响因子：
9.3
通讯作者：
Shapiro MD
中科院分区：
文献类型：
--
作者：
Chevli PA;Freedman BI;Hsu FC;Xu J;Rudock ME;Ma L;Parks JS;Palmer ND;Shapiro MD
心血管疾病（CVD）的发病率正在增加，部分原因是糖尿病流行。需要新的预测工具和可修改的治疗目标来加强风险评估和管理。在糖尿病心脏研究（DHS）中研究了血浆代谢产物与亚临床动脉粥样硬化的相关性，DHS是一项2型糖尿病（T2 D）富集队列。该分析包括700名DHS参与者，438名非洲裔美国人（AA）和262名欧洲裔美国人（EA），其中冠状动脉钙（CAC）使用ECG门控计算机断层扫描进行评估。使用液相色谱-质谱法的血浆代谢组学鉴定了853种已知代谢物。一个包含广义估计方程的祖先特异性边际模型检查了代谢物与CAC之间的相关性（对数转换（CAC + 1）作为结局指标）。调整模型的年龄、性别、BMI、糖尿病病程、血浆采集日期、血浆采集与CT检查之间的时间、低密度脂蛋白胆固醇（LDL-C）和他汀类药物的使用。在FDR校正的p值< 0.05时，AA中有33种代谢物与CAC相关，EA中有36种代谢物与CAC相关。雄激素类固醇，脂肪酸，磷脂酰胆碱和胆汁酸代谢子途径与CAC在AA，而脂肪酸，lysoplasmalogen，支链氨基酸（BCAA）子途径与CAC在EA。在AA和EA DHS参与者中，显著不同的代谢特征与亚临床冠状动脉粥样硬化相关。在线版本包含补充材料，可通过10.1186/s12933-021-01419-y获取。
Incidence rates of cardiovascular disease (CVD) are increasing, partly driven by the diabetes epidemic. Novel prediction tools and modifiable treatment targets are needed to enhance risk assessment and management. Plasma metabolite associations with subclinical atherosclerosis were investigated in the Diabetes Heart Study (DHS), a cohort enriched for type 2 diabetes (T2D). The analysis included 700 DHS participants, 438 African Americans (AAs), and 262 European Americans (EAs), in whom coronary artery calcium (CAC) was assessed using ECG-gated computed tomography. Plasma metabolomics using liquid chromatography-mass spectrometry identified 853 known metabolites. An ancestry-specific marginal model incorporating generalized estimating equations examined associations between metabolites and CAC (log-transformed (CAC + 1) as outcome measure). Models were adjusted for age, sex, BMI, diabetes duration, date of plasma collection, time between plasma collection and CT exam, low-density lipoprotein cholesterol (LDL-C), and statin use. At an FDR-corrected p-value < 0.05, 33 metabolites were associated with CAC in AAs and 36 in EAs. The androgenic steroids, fatty acid, phosphatidylcholine, and bile acid metabolism subpathways were associated with CAC in AAs, whereas fatty acid, lysoplasmalogen, and branched-chain amino acid (BCAA) subpathways were associated with CAC in EAs. Strikingly different metabolic signatures were associated with subclinical coronary atherosclerosis in AA and EA DHS participants. The online version contains supplementary material available at 10.1186/s12933-021-01419-y.
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影响因子：
16.2
作者：
Agarwal S;Cox AJ;Herrington DM;Jorgensen NW;Xu J;Freedman BI;Carr JJ;Bowden DW
通讯作者：
Bowden DW
影响因子：
7.7
作者：
Floegel A;Stefan N;Yu Z;Mühlenbruch K;Drogan D;Joost HG;Fritsche A;Häring HU;Hrabě de Angelis M;Peters A;Roden M;Prehn C;Wang-Sattler R;Illig T;Schulze MB;Adamski J;Boeing H;Pischon T
通讯作者：
Pischon T
影响因子：
37.8
作者：
Cheng S;Rhee EP;Larson MG;Lewis GD;McCabe EL;Shen D;Palma MJ;Roberts LD;Dejam A;Souza AL;Deik AA;Magnusson M;Fox CS;O'Donnell CJ;Vasan RS;Melander O;Clish CB;Gerszten RE;Wang TJ
通讯作者：
Wang TJ
DOI：
10.1001/jama.2016.21043
发表时间：
2017-02-21
期刊：
JAMA
影响因子：
--
作者：
Budoff MJ;Ellenberg SS;Lewis CE;Mohler ER 3rd;Wenger NK;Bhasin S;Barrett-Connor E;Swerdloff RS;Stephens-Shields A;Cauley JA;Crandall JP;Cunningham GR;Ensrud KE;Gill TM;Matsumoto AM;Molitch ME;Nakanishi R;Nezarat N;Matsumoto S;Hou X;Basaria S;Diem SJ;Wang C;Cifelli D;Snyder PJ
通讯作者：
Snyder PJ
DOI：
10.1161/hcg.0000000000000032
发表时间：
2017-04
期刊：
Circulation. Cardiovascular genetics
影响因子：
--
作者：
Cheng S;Shah SH;Corwin EJ;Fiehn O;Fitzgerald RL;Gerszten RE;Illig T;Rhee EP;Srinivas PR;Wang TJ;Jain M;American Heart Association Council on Functional Genomics and Translational Biology; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Stroke Council
通讯作者：
American Heart Association Council on Functional Genomics and Translational Biology; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Stroke Council