Anti-Aspergillus Activities of the Respiratory Epithelium in Health and Disease.
Anti-Aspergillus Activities of the Respiratory Epithelium in Health and Disease.
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DOI：
10.3390/jof4010008
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发表时间：
2018-01-08
期刊：
影响因子：
--
通讯作者：
Bignell EM
中科院分区：
文献类型：
--
作者：
Bertuzzi M;Hayes GE;Icheoku UJ;van Rhijn N;Denning DW;Osherov N;Bignell EM
除了气体交换外，呼吸上皮还发挥着多种作用，是肺无菌和炎症稳态的主要保管人。吸入真菌孢子对肺完整性构成持续的抗原性和潜在的致病性挑战，人类呼吸道黏膜已经形成了各种耐受性和防御策略。然而，呼吸系统疾病和免疫功能障碍经常使人的肺部容易受到真菌疾病的影响，其中最常见的是曲霉病，这是一组由吸入烟曲霉孢子引起的综合征。吸入曲霉菌孢子与呼吸道上皮细胞进行多种相互作用，其机制基础刚刚被认为是疾病的重要驱动因素，也是可能的治疗靶点。在这篇小型综述中，我们考察了目前对曲霉与上皮相互作用的理解，并基于该领域的最新发展，我们探讨了两种明显相反的思想流派，它们认为曲霉孢子的上皮摄取要么是治疗性的，要么是加重疾病的事件。
Respiratory epithelia fulfil multiple roles beyond that of gaseous exchange, also acting as primary custodians of lung sterility and inflammatory homeostasis. Inhaled fungal spores pose a continual antigenic, and potentially pathogenic, challenge to lung integrity against which the human respiratory mucosa has developed various tolerance and defence strategies. However, respiratory disease and immune dysfunction frequently render the human lung susceptible to fungal diseases, the most common of which are the aspergilloses, a group of syndromes caused by inhaled spores of Aspergillus fumigatus. Inhaled Aspergillus spores enter into a multiplicity of interactions with respiratory epithelia, the mechanistic bases of which are only just becoming recognized as important drivers of disease, as well as possible therapeutic targets. In this mini-review we examine current understanding of Aspergillus-epithelial interactions and, based upon the very latest developments in the field, we explore two apparently opposing schools of thought which view epithelial uptake of Aspergillus spores as either a curative or disease-exacerbating event.
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影响因子：
4.2
作者：
Alekseeva L;Huet D;Féménia F;Mouyna I;Abdelouahab M;Cagna A;Guerrier D;Tichanné-Seltzer V;Baeza-Squiban A;Chermette R;Latgé JP;Berkova N
通讯作者：
Berkova N
影响因子：
5.2
作者：
Escobar N;Ordonez SR;Wösten HA;Haas PJ;de Cock H;Haagsman HP
通讯作者：
Haagsman HP
影响因子：
3.1
作者：
AMITANI, R;TAYLOR, G;WILSON, R
通讯作者：
WILSON, R
影响因子：
3.1
作者：
Bidula, Stefan;Kenawy, Hany;Schelenz, Silke
通讯作者：
Schelenz, Silke
影响因子：
30.3
作者：
Akoumianaki, Tonia;Kyrmizi, Irene;Chamilos, Georgios
通讯作者：
Chamilos, Georgios