Different pediatric brain tumors are associated with different gene expression profiling
Different pediatric brain tumors are associated with different gene expression profiling
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DOI：
10.1016/j.acthis.2015.02.010
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发表时间：
2015-01-01
影响因子：
2.5
通讯作者：
Malaguarner, Lucia
中科院分区：
文献类型：
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作者：
Di Rosa, Michelino;Sanfilippo, Cristina;Malaguarner, Lucia
恶性脑肿瘤是最常见的儿科实体肿瘤，也是儿童癌症死亡的主要原因。这些肿瘤包括几种组织学亚型。由于脑肿瘤的生长和分裂等特殊性质，脑肿瘤的检查和结果分析并不简单。到目前为止，还缺乏已被验证和临床应用于儿科脑肿瘤的有用的生物标志物。为了鉴定新的遗传改变，我们使用微阵列数据集，几丁质酶作为CNS肿瘤的新的潜在生物标志物。几丁质酶的调制也证实了在不同的组织学亚型。我们的研究表明，不同的几丁质酶表达模式的特点不同的组织学亚型。此外，评估其他溶酶体酶如糖苷酶和蛋白酶，我们发现属于糖苷酶家族的NEU4、CTBS和GBA 2以及属于蛋白酶家族的CTSC、CTSK和CTSF受到不同的调节。在这些酶中的一些最终可以用作特定类型的CNS肿瘤的生物标志物之前，需要进行进一步的研究。(C)2015 Elsevier GmbH. All rights reserved.
Malignant brain tumors are the most common pediatric solid tumors and are the leading cause of death from childhood cancers. These tumors include several histologic subtypes. Due to the particular properties of brain tumors, such as growth and division, examination of brain tumors and the analysis of results are not simple. Up to date there is a dearth of useful biomarkers that have been validated and clinically implemented for pediatric brain tumors. In order to identify the new genetic alterations we recognized, using microarray dataset, chitinases as new potential biomarkers of CNS tumors. The modulation of chitinases was confirmed also in the different histologic subtypes. Our study revealed that distinct patterns of chitinases expression characterize the diverse histological subtypes. In addition evaluating other lisosomal enzymes such as glycosidases and proteases we found that NEU4, CTBS and GBA2 belonging to glycosidases family and CTSC, CTSK and CTSF belonging to proteases family were differently modulated. Future investigations are needed to be performed before some of these enzymes could finally be used as biomarkers of specific types of CNS neoplasms. (C) 2015 Elsevier GmbH. All rights reserved.