Breast cancer risk factors according to combined estrogen and progesterone receptor status: A case-control analysis
Breast cancer risk factors according to combined estrogen and progesterone receptor status: A case-control analysis
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DOI：
10.1093/oxfordjournals.aje.a009271
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发表时间：
1997-08-15
影响因子：
5
通讯作者：
Dubrow, R
中科院分区：
文献类型：
--
作者：
Yoo, KY;Tajima, K;Dubrow, R
根据激素受体状态的不同，乳腺癌对内分泌治疗的反应程度不同，雌激素和孕激素受体阳性的肿瘤反应最好。作者假设，可能由内源性激素介导的生殖风险因素也会因受体状态的不同而不同，两种受体均阳性的肿瘤将表现出最高的风险。有关危险因素的信息是从1988年至1992年日本名古屋爱知癌症中心医院的1154例乳腺癌病例和21714例非癌症对照中获得的。已知受体状态的病例有40%，对于给定的危险因素，对不同受体状态的乳腺癌与普通对照组的优势比进行多因素Logistic回归分析，不同的雌激素受体状态的危险因素没有显著差异，但诊断/面谈时的年龄、职业、月经初潮年龄、20-29岁的月经规律，吸烟根据孕激素受体状态的不同有显著或接近显著的影响。根据联合雌激素和孕激素受体状态对病例进行分层，表明雌激素受体状态并不改变这种效果的差异。这项研究不支持生殖因素根据激素受体状态存在风险梯度的假设。作者建议，一些危险因素根据孕激素受体状态的不同而不同，这一发现应该在进一步的研究中进行。
Breast cancers demonstrate a gradient of responsiveness to endocrine therapy according to hormone receptor status, with tumors positive for both estrogen and progesterone receptors responding most favorably. The authors hypothesized that reproductive risk factors, which are probably mediated by endogenous hormones, would also differ according to receptor status, and that tumors positive for both receptors would exhibit the highest risk. information on risk factors was obtained from 1,154 breast cancer cases and 21,714 cancer-free controls at the Aichi Cancer Center Hospital, Nagoya, Japan between 1988 and 1992. Receptor status was known for 40% of cases, For a given risk factor, odds ratios with respect to the common control group for breast cancers of differing receptor status were compared using multiple polytomous logistic regression, Risk factors did not differ significantly according to estrogen receptor status, However, age at diagnosis/interview, occupation, age at menarche, menstrual regularity at ages 20-29 years, and cigarette smoking differed significantly or borderline significantly in effect according to progesterone receptor status. Stratification of cases according to joint estrogen and progesterone receptor status indicated that estrogen receptor status did not modify this difference in effect. This study did not support the hypothesis oi a gradient of risk for reproductive factors according to hormone receptor status. The authors recommend that the finding that some risk factors differ according to progesterone receptor status should be pursued in further studies.